ArticlePloS one2016
Within-Host Models of High and Low Pathogenic Influenza Virus Infections: The Role of Macrophages.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- Article
- Mathematical Model of Influenza Infection Suggests JAK-STAT Activity Drives Severe Pathologies in Juvenile Mice.Frontiers in applied mathematics and statistics · 2025Article
- Measles Infection Dose Responses: Insights from Mathematical Modeling.Bulletin of mathematical biology · 2024Article
- Mathematical Modeling Suggests That Monocyte Activity May Drive Sex Disparities during Influenza Infection.Viruses · 2024Article
- Enhanced viral infectivity and reduced interferon production are associated with high pathogenicity for influenza viruses.PLoS computational biology · 2023Article
- Utility of HumanJournal of virology · 2023Article
- Prediction of transport, deposition, and resultant immune response of nasal spray vaccine droplets using a CFPD-HCD model in a 6-year-old upper airway geometry to potentially prevent COVID-19.Experimental and computational multiphase flow · 2023Article
- A simple model of COVID-19 explains disease severity and the effect of treatments.Scientific reports · 2022Article
- Article
- Optimizing antiviral therapy for COVID-19 with learned pathogenic model.Scientific reports · 2022Article
- COVID-19 virtual patient cohort suggests immune mechanisms driving disease outcomes.PLoS pathogens · 2021Article
- COVID-19 virtual patient cohort reveals immune mechanisms driving disease outcomes.bioRxiv : the preprint server for biology · 2021Article
- Ferreting Out Influenza Virus Pathogenicity and Transmissibility: Past and Future Risk Assessments in the Ferret Model.Cold Spring Harbor perspectives in medicine · 2020Review
- Antiviral activity of iridoid glycosides extracted from Fructus Gardeniae against influenza A virus by PACT-dependent suppression of viral RNA replication.Scientific reports · 2020Article
- In-host Mathematical Modelling of COVID-19 in Humans.Annual reviews in control · 2020Article
- Avian Flavivirus Infection of Monocytes/Macrophages by Extensive Subversion of Host Antiviral Innate Immune Responses.Journal of virology · 2019Article
- Correction: Within-Host Models of High and Low Pathogenic Influenza Virus Infections: The Role of Macrophages.PloS one · 2019Article
- Exploring the impact of inoculum dose on host immunity and morbidity to inform model-based vaccine design.PLoS computational biology · 2018Article
- Monocytes and Macrophages as Viral Targets and Reservoirs.International journal of molecular sciences · 2018Review
- Enhanced Replication of Virulent Newcastle Disease Virus in Chicken Macrophages Is due to Polarized Activation of Cells by Inhibition of TLR7.Frontiers in immunology · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The World Health Organization identifies influenza as a major public health problem. While the strains commonly circulating in humans usually do not cause severe pathogenicity in healthy adults, some strains that have infected humans, such as H5N1, can cause high morbidity and mortality. Based on the severity of the disease, influenza viruses are sometimes categorized as either being highly pathogenic (HP) or having low pathogenicity (LP). The reasons why some strains are LP and others HP are not fully understood. While there are likely multiple mechanisms of interaction between the virus and the immune response that determine LP versus HP outcomes, we focus here on one component, namely macrophages (MP). There is some evidence that MP may both help fight the infection and become productively infected with HP influenza viruses. We developed mathematical models for influenza infections which explicitly included the dynamics and action of MP. We fit these models to viral load and macrophage count data from experimental infections of mice with LP and HP strains. Our results suggest that MP may not only help fight an influenza infection but may contribute to virus production in infections with HP viruses. We also explored the impact of combination therapies with antivirals and anti-inflammatory drugs on HP infections. Our study suggests a possible mechanism of MP in determining HP versus LP outcomes, and how different interventions might affect infection dynamics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.