Evidence map›Paper›PMID 26918600›Full record

ArticleOncotarget2017

Germline genetic variations in PDZD2 and ITPR2 genes are associated with clear cell renal cell carcinoma in Chinese population.

Ning Zhang, Yishuo Wu, Jian Gong, Kaiwen Li, Xiaolin Lin, Haitao Chen, Yang Yu, Yuancheng Gou, Jiangang Hou, Deke Jiang and 4 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Validation ofFrontiers in medicine · 2026
    Article
  2. Article
  3. Cryptic binding properties of a transient folding intermediate in a PDZ tandem repeat.Protein science : a publication of the Protein Society · 2022
    Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Ning ZhangDepartment of Urology, Huashan Hospital, Fudan University, Shanghai, PR China.
Yishuo WuDepartment of Urology, Huashan Hospital, Fudan University, Shanghai, PR China.
Jian GongFudan Institute of Urology, Huashan Hospital, Fudan University, Shanghai, PR China.
Kaiwen LiDepartment of Urology, Sun Yat-sen Memorial Hospital, Sun Yet-sen University, Guandong, PR China.
Xiaolin LinFudan Institute of Urology, Huashan Hospital, Fudan University, Shanghai, PR China.
Haitao ChenCenter for Genetic Epidemiology, School of Life Sciences, Fudan University, Shanghai, PR China.
Yang YuDepartment of Urology, Huashan Hospital, Fudan University, Shanghai, PR China.
Yuancheng GouDepartment of Urology, Huashan Hospital, Fudan University, Shanghai, PR China.
Jiangang HouDepartment of Urology, Huashan Hospital, Fudan University, Shanghai, PR China.
Deke JiangState Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, PR China.
Rong NaDepartment of Urology, Huashan Hospital, Fudan University, Shanghai, PR China.
Xiang WangDepartment of Urology, Huashan Hospital, Fudan University, Shanghai, PR China.
Qiang DingDepartment of Urology, Huashan Hospital, Fudan University, Shanghai, PR China.
Jianfeng XuFudan Institute of Urology, Huashan Hospital, Fudan University, Shanghai, PR China.
Huashan Hospital · CNFudan University · CNSun Yat-sen Memorial Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genome-wide association studies (GWAS) of renal cell carcinoma (RCC) have identified single nucleotide polymorphisms (SNPs) associated with RCC in European and African American population. In this study, we evaluated whether these SNPs are associated with clear cell RCC (ccRCC) in Chinese population. All reported RCC risk-associated SNPs from GWAS were evaluated in 346 ccRCC cases and 1,130 controls. Rs10054504 (at PDZD2, Odds ratio, OR = 0.71, 95%CI:0.59-0.86, P = 0.0006), rs718314 (at ITPR2, OR = 0.56, 95%CI:0.45-0.69, P = 5.26×10-8) and rs1049380 (at ITPR2, by dominant model, OR = 1.58, 95%CI:1.18-2.13, P = 0.0025) were significantly associated with ccRCC risk in Chinese population. To conclude, genetic variations in PDZD2 and ITPR2 are ccRCC-risk associated in Chinese population.

Indexed as

Genetic VariationGerm-Line MutationAdaptor Proteins, Signal TransducingAdultAgedAllelesCarcinoma, Renal CellCase-Control StudiesCell Adhesion MoleculesChinaFemaleGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHumansInositol 1,4,5-Trisphosphate ReceptorsAdaptor Proteins, Signal TransducingCell Adhesion MoleculesInositol 1,4,5-Trisphosphate ReceptorsITPR2 protein, humanNeoplasm ProteinsPDZD2 protein, humanChinesegenome-wide associationrenal cell carcinomaSNPs

Identifiers

PMID26918600
PMCPMC5421839
OpenAlexW2285683364

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.