Evidence map›Paper›PMID 26918319›Full record

ReviewNMR in biomedicine2017

Susceptibility-based time-resolved whole-organ and regional tissue oximetry.

Felix W Wehrli, Audrey P Fan, Zachary B Rodgers, Erin K Englund, Michael C Langham

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in NMR in biomedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Sensitivity assessment of QSM+qBOLD (or QQ) in detecting elevated oxygen extraction fraction (OEF) in physiological change.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025
    Article
  2. Recent Advances in MR Imaging-based Quantification of Brain Oxygen Metabolism.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2024
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  15. Cerebral oxygen extraction fraction (OEF): Comparison of challenge-free gradient echo QSM+qBOLD (QQ) withJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Article
  16. Cerebral metabolic rate of oxygen during transition from wakefulness to sleep measured with high temporal resolution OxFlow MRI with concurrent EEG.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Article
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  19. Normal variations in brain oxygen extraction fraction are partly attributed to differences in end-tidal COJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Felix W WehrliLaboratory for Structural, Physiologic and Functional Imaging, Department of Radiology, Perelman School of Medicine, University of Pennsylvania.
Audrey P FanLucas Center for Imaging, Department of Radiology, Stanford University, James H. Clark Center, 318 Campus Drive, Suite S170, Stanford, CA 94305.
Zachary B RodgersLaboratory for Structural, Physiologic and Functional Imaging, Department of Radiology, Perelman School of Medicine, University of Pennsylvania.
Erin K EnglundLaboratory for Structural, Physiologic and Functional Imaging, Department of Radiology, Perelman School of Medicine, University of Pennsylvania.
Michael C LanghamLaboratory for Structural, Physiologic and Functional Imaging, Department of Radiology, Perelman School of Medicine, University of Pennsylvania.

Funding

MRI Assessment of Vascular ReactivityR01HL109545 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI WEHRLI, FELIX W · 2011 to 2014
$2.1M
Neurometabolic Assessment of Obstructive Sleep Apnea by MRIR01HL122754 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI WEHRLI, FELIX W · 2015 to 2018
$1.7M
Surrogate measures of endothelial dysfunction with integrated MRIK25HL111422 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI LANGHAM, MICHAEL · 2012 to 2016
$702k
NHLBI NIH HHS K25 HL111422NHLBI NIH HHS R01 HL109545NHLBI NIH HHS R01 HL122754
6 · The paper itself

Abstract

The magnetism of hemoglobin - being paramagnetic in its deoxy and diamagnetic in its oxy state - offers unique opportunities to probe oxygen metabolism in blood and tissues. The magnetic susceptibility χ of blood scales linearly with blood oxygen saturation, which can be obtained by measuring the magnetic field ΔB of the intravascular MR signal relative to tissue. In contrast to χ, the induced field ΔB is non-local. Therefore, to obtain the intravascular susceptibility Δχ relative to adjoining tissue from the measured ΔB demands solution of an inverse problem. Fortunately, for ellipsoidal structures, to which a straight, cylindrically shaped blood vessel segment conforms, the solution is trivial. The article reviews the principle of MR susceptometry-based blood oximetry. It then discusses applications for quantification of whole-brain oxygen extraction - typically on the basis of a measurement in the superior sagittal sinus - and, in conjunction with total cerebral blood flow, the cerebral metabolic rate of oxygen (CMRO

Indexed as

AnimalsBrainHumansImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMolecular ImagingOximetryOxygenReproducibility of ResultsSensitivity and SpecificityTissue DistributionOxygenApplications, Other functional MRI methodsEndogenous Contrast MethodsFunctional MRI (fMRI) MethodsMethods and Engineering, CMRO2Methods and Engineering, Normal brainNeurologicalSusceptibility weighted imaging

Identifiers

PMID26918319
PMCPMC5001941

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.