Evidence map›Paper›PMID 26918228›Full record

ArticleNanophotonics (Berlin, Germany)2012

Label-free detection with high-Q microcavities: a review of biosensing mechanisms for integrated devices.

Frank Vollmer, Lan Yang

Abstract read
In one paragraph

Article in Nanophotonics (Berlin, Germany), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Laser-emitting aqueous bioreactors for ultrasensitive bioactivity analysis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Ultrasound sensing with optical microcavities.Light, science & applications · 2024
    Review
  12. Real-time imaging of standing-wave patterns in microresonators.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  13. Article
  14. Roadmap on optical sensors.Journal of optics (2010) · 2024
    Review
  15. Multimode sensing based on optical microcavities.Frontiers of optoelectronics · 2023
    Review
  16. Article
  17. Article
  18. Non-Hermitian Topolectrical Circuit Sensor with High Sensitivity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  19. Article
  20. Review

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Frank VollmerMax Planck Institute for the Science of Light, Laboratory of Nanophotonics and Biosensing, G. Scharowsky Str. 1, 91058 Erlangen, Germany.
Lan YangElectrical and Systems Engineering Department, Washington University, St. Louis, MO 63130, USA.

Funding

Optical microresonator biosensors for high-throughput, real-time analysis of cellR01GM095906 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI VOLLMER, FRANK · 2011 to 2015
$1.8M
NIGMS NIH HHS R01 GM095906
6 · The paper itself

Abstract

Optical microcavities that confine light in high-Q resonance promise all of the capabilities required for a successful next-generation microsystem biodetection technology. Label-free detection down to single molecules as well as operation in aqueous environments can be integrated cost-effectively on microchips, together with other photonic components, as well as electronic ones. We provide a comprehensive review of the sensing mechanisms utilized in this emerging field, their physics, engineering and material science aspects, and their application to nanoparticle analysis and biomolecular detection. We survey the most recent developments such as the use of mode splitting for self-referenced measurements, plasmonic nanoantennas for signal enhancements, the use of optical force for nanoparticle manipulation as well as the design of active devices for ultra-sensitive detection. Furthermore, we provide an outlook on the exciting capabilities of functionalized high-Q microcavities in the life sciences.

Indexed as

biosensingintegrated photonicsmicrolasersnanoparticle detectionoptical microcavitiesoptical resonatoroptical trappingplasmonics

Identifiers

PMID26918228
PMCPMC4764104

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.