ArticleInternational journal of medical sciences2016
Identification of microRNAs in Throat Swab as the Biomarkers for Diagnosis of Influenza.
Article in International journal of medical sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Exploring the regulatory role of small RNAs in modulating host-pathogen interactions: implications for bacterial and viral infections.Molecular biology reports · 2025Review
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- MicroRNA expression profiling in the lungs of genetically different Ri chicken lines against the highly pathogenic avian influenza H5N1 virus.Journal of animal science and technology · 2023Article
- Role of microRNA-34b-5p in cancer and injury: how does it work?Cancer cell international · 2022Review
- Identifying MicroRNA Markers That Predict COVID-19 Severity Using Machine Learning Methods.Life (Basel, Switzerland) · 2022Article
- Micro-Players of Great Significance-Host microRNA Signature in Viral Infections in Humans and Animals.International journal of molecular sciences · 2022Review
- Article
- Comparative Mucous miRomics in Cynoglossus semilaevis Related to Vibrio harveyi Caused Infection.Marine biotechnology (New York, N.Y.) · 2021Article
- Interplay between host non-coding RNAs and influenza viruses.RNA biology · 2021Review
- miR-1975 serves as an indicator of clinical severity upon influenza infection.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021Article
- Can Measurements of Inflammatory Biomarkers be Used to Spot Respiratory Viral Infections?Viruses · 2020Article
- Article
- miRNA repertoire and host immune factor regulation upon avian coronavirus infection in eggs.Archives of virology · 2020Article
- MicroRNAs in Asthma and Respiratory Infections: Identifying Common Pathways.Allergy, asthma & immunology research · 2020Review
- MicroRNA-132-3p suppresses type I IFN response through targeting IRF1 to facilitate H1N1 influenza A virus infection.Bioscience reports · 2019Article
- Highly Sensitive in Vitro Diagnostic System of Pandemic Influenza A (H1N1) Virus Infection with Specific MicroRNA as a Biomarker.ACS omega · 2019Article
- microRNAs in viral acute respiratory infections: immune regulation, biomarkers, therapy, and vaccines.ExRNA · 2019Review
- Combining micro-RNA and protein sequencing to detect robust biomarkers for Graves' disease and orbitopathy.Scientific reports · 2018Article
- Potential Role of MicroRNAs in the Regulation of Antiviral Responses to Influenza Infection.Frontiers in immunology · 2018Review
- Involvement of Host Non-Coding RNAs in the Pathogenesis of the Influenza Virus.International journal of molecular sciences · 2016Review
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInfluenza is a serious worldwide disease that captures global attention in the past few years after outbreaks. The recent discoveries of microRNA (miRNA) and its unique expression profile in influenza patients have offered a new method for early influenza diagnosis. The aim of this study was to examine the utility of miRNAs for the diagnosis of influenza.
methodsThirteen selected miRNAs were investigated with the hosts' throat swabs (25 H1N1, 20 H3N2, 20 influenza B and 21 healthy controls) by real-time quantitative polymerase chain reaction (RT-qPCR) using U6 snRNA as endogenous control for normalization, and receiver operating characteristic (ROC) curve/Area under curve (AUC) for analysis.
resultsmiR-29a-3p, miR-30c-5p, miR-34c-3p and miR-181a-5p are useful biomarkers for influenza A detection; and miR-30c-5p, miR-34b-5p, miR-205-5p and miR-449b-5p for influenza B detection. Also, use of both miR-30c-5p and miR-34c-3p (AUC=0.879); and miR-30c-5p and miR-449b-5p (AUC=0.901) are better than using one miRNA to confirm influenza A and influenza B infection, respectively.
conclusionsGiven its simplicity, non-invasiveness and specificity, we found that the throat swab-derived miRNAs miR-29a-3p, miR-30c-5p, miR-34b-5p, miR-34c-3p, miR-181a-5p, miR-205-5p and miR-449b-5p are a useful tool for influenza diagnosis on influenza A and B.
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