Evidence map›Paper›PMID 26917984›Full record

ReviewBiomedical engineering and computational biology2016

Artificial Neural Networks as Decision Support Tools in Cytopathology: Past, Present, and Future.

Abraham Pouliakis, Efrossyni Karakitsou, Niki Margari, Panagiotis Bountris, Maria Haritou, John Panayiotides, Dimitrios Koutsouris, Petros Karakitsos

Abstract readReview
In one paragraph

Review in Biomedical engineering and computational biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. A brief review of cytology in dentistry.British dental journal · 2024
    Review
  5. Article
  6. Article
  7. Current status of machine learning in thyroid cytopathology.Journal of pathology informatics · 2023
    Review
  8. Trends in AI-powered Classification of Thyroid Neoplasms Based on Histopathology Images - a Systematic Review.Acta informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH · 2023
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. A Calibrated Multiexit Neural Network for Detecting Urothelial Cancer Cells.Computational and mathematical methods in medicine · 2021
    Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Article
  20. Factors associated withTranslational cancer research · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Abraham PouliakisDepartment of Cytopathology, National and Kapodistrian University of Athens, Medical School, Attikon University Hospital, Athens, Greece.
Efrossyni Karakitsou2nd Department of Pathology, National and Kapodistrian University of Athens, Medical School, Attikon University Hospital, Athens, Greece.
Niki MargariDepartment of Cytopathology, National and Kapodistrian University of Athens, Medical School, Attikon University Hospital, Athens, Greece.
Panagiotis BountrisBiomedical Engineering Laboratory, National Technical University of Athens, Athens, Greece.
Maria HaritouInstitute of Communication and Computer Systems, Athens, Greece.
John Panayiotides2nd Department of Pathology, National and Kapodistrian University of Athens, Medical School, Attikon University Hospital, Athens, Greece.
Dimitrios KoutsourisBiomedical Engineering Laboratory, National Technical University of Athens, Athens, Greece.
Petros KarakitsosDepartment of Cytopathology, National and Kapodistrian University of Athens, Medical School, Attikon University Hospital, Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aims to analyze the role of artificial neural networks (ANNs) in cytopathology. More specifically, it aims to highlight the importance of employing ANNs in existing and future applications and in identifying unexplored or poorly explored research topics. STUDY

designA systematic search was conducted in scientific databases for articles related to cytopathology and ANNs with respect to anatomical places of the human body where cytopathology is performed. For each anatomic system/organ, the major outcomes described in the scientific literature are presented and the most important aspects are highlighted.

resultsThe vast majority of ANN applications are related to cervical cytopathology, specifically for the ANN-based, semiautomated commercial diagnostic system PAPNET. For cervical cytopathology, there is a plethora of studies relevant to the diagnostic accuracy; in addition, there are also efforts evaluating cost-effectiveness and applications on primary, secondary, or hybrid screening. For the rest of the anatomical sites, such as the gastrointestinal system, thyroid gland, urinary tract, and breast, there are significantly less efforts relevant to the application of ANNs. Additionally, there are still anatomical systems for which ANNs have never been applied on their cytological material.

conclusionsCytopathology is an ideal discipline to apply ANNs. In general, diagnosis is performed by experts via the light microscope. However, this approach introduces subjectivity, because this is not a universal and objective measurement process. This has resulted in the existence of a gray zone between normal and pathological cases. From the analysis of related articles, it is obvious that there is a need to perform more thorough analyses, using extensive number of cases and particularly for the nonexplored organs. Efforts to apply such systems within the laboratory test environment are required for their future uptake.

Indexed as

artificial intelligenceartificial neural networksautomationcomputer-assisted diagnosiscytologycytopathologydecision supportneural networksreview

Identifiers

PMID26917984
PMCPMC4760671

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.