Evidence map›Paper›PMID 26917814›Full record

ArticleCirculation. Arrhythmia and electrophysiology2016

Association of Left Atrial Local Conduction Velocity With Late Gadolinium Enhancement on Cardiac Magnetic Resonance in Patients With Atrial Fibrillation.

Kotaro Fukumoto, Mohammadali Habibi, Esra Gucuk Ipek, Sohail Zahid, Irfan M Khurram, Stefan L Zimmerman, Vadim Zipunnikov, David Spragg, Hiroshi Ashikaga, Natalia Trayanova and 6 more

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In one paragraph

Article in Circulation. Arrhythmia and electrophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed.

  1. Optimization of late gadolinium enhancement cardiovascular magnetic resonance imaging of post-ablation atrial scar: a cross-over study.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2018
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  7. Effective ablation settings that predict chronic scar after atrial ablation with HELIOSTAR™ multi-electrode radiofrequency balloon catheter.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Kotaro FukumotoFrom the Section of Cardiac Electrophsyiology (K.F., M.H., E.G.I., I.M.K., D.S., H.A., N.T., G.F.T., J.R., J.E.M., R.D.B., H.C., S.N.), Department of Biomedical Engineering (S.Z., H.A., N.T., R.D.B.), Department of Radiology (S.L.Z.), Department of Biostatistics (V.Z.), and Department of Epidemiology (S.N.), Johns Hopkins University, Baltimore, MD.
Mohammadali HabibiFrom the Section of Cardiac Electrophsyiology (K.F., M.H., E.G.I., I.M.K., D.S., H.A., N.T., G.F.T., J.R., J.E.M., R.D.B., H.C., S.N.), Department of Biomedical Engineering (S.Z., H.A., N.T., R.D.B.), Department of Radiology (S.L.Z.), Department of Biostatistics (V.Z.), and Department of Epidemiology (S.N.), Johns Hopkins University, Baltimore, MD.
Esra Gucuk IpekFrom the Section of Cardiac Electrophsyiology (K.F., M.H., E.G.I., I.M.K., D.S., H.A., N.T., G.F.T., J.R., J.E.M., R.D.B., H.C., S.N.), Department of Biomedical Engineering (S.Z., H.A., N.T., R.D.B.), Department of Radiology (S.L.Z.), Department of Biostatistics (V.Z.), and Department of Epidemiology (S.N.), Johns Hopkins University, Baltimore, MD.
Sohail ZahidFrom the Section of Cardiac Electrophsyiology (K.F., M.H., E.G.I., I.M.K., D.S., H.A., N.T., G.F.T., J.R., J.E.M., R.D.B., H.C., S.N.), Department of Biomedical Engineering (S.Z., H.A., N.T., R.D.B.), Department of Radiology (S.L.Z.), Department of Biostatistics (V.Z.), and Department of Epidemiology (S.N.), Johns Hopkins University, Baltimore, MD.
Irfan M KhurramFrom the Section of Cardiac Electrophsyiology (K.F., M.H., E.G.I., I.M.K., D.S., H.A., N.T., G.F.T., J.R., J.E.M., R.D.B., H.C., S.N.), Department of Biomedical Engineering (S.Z., H.A., N.T., R.D.B.), Department of Radiology (S.L.Z.), Department of Biostatistics (V.Z.), and Department of Epidemiology (S.N.), Johns Hopkins University, Baltimore, MD.
Stefan L ZimmermanFrom the Section of Cardiac Electrophsyiology (K.F., M.H., E.G.I., I.M.K., D.S., H.A., N.T., G.F.T., J.R., J.E.M., R.D.B., H.C., S.N.), Department of Biomedical Engineering (S.Z., H.A., N.T., R.D.B.), Department of Radiology (S.L.Z.), Department of Biostatistics (V.Z.), and Department of Epidemiology (S.N.), Johns Hopkins University, Baltimore, MD.
Vadim ZipunnikovFrom the Section of Cardiac Electrophsyiology (K.F., M.H., E.G.I., I.M.K., D.S., H.A., N.T., G.F.T., J.R., J.E.M., R.D.B., H.C., S.N.), Department of Biomedical Engineering (S.Z., H.A., N.T., R.D.B.), Department of Radiology (S.L.Z.), Department of Biostatistics (V.Z.), and Department of Epidemiology (S.N.), Johns Hopkins University, Baltimore, MD.
David SpraggFrom the Section of Cardiac Electrophsyiology (K.F., M.H., E.G.I., I.M.K., D.S., H.A., N.T., G.F.T., J.R., J.E.M., R.D.B., H.C., S.N.), Department of Biomedical Engineering (S.Z., H.A., N.T., R.D.B.), Department of Radiology (S.L.Z.), Department of Biostatistics (V.Z.), and Department of Epidemiology (S.N.), Johns Hopkins University, Baltimore, MD.
Hiroshi AshikagaFrom the Section of Cardiac Electrophsyiology (K.F., M.H., E.G.I., I.M.K., D.S., H.A., N.T., G.F.T., J.R., J.E.M., R.D.B., H.C., S.N.), Department of Biomedical Engineering (S.Z., H.A., N.T., R.D.B.), Department of Radiology (S.L.Z.), Department of Biostatistics (V.Z.), and Department of Epidemiology (S.N.), Johns Hopkins University, Baltimore, MD.
Natalia TrayanovaFrom the Section of Cardiac Electrophsyiology (K.F., M.H., E.G.I., I.M.K., D.S., H.A., N.T., G.F.T., J.R., J.E.M., R.D.B., H.C., S.N.), Department of Biomedical Engineering (S.Z., H.A., N.T., R.D.B.), Department of Radiology (S.L.Z.), Department of Biostatistics (V.Z.), and Department of Epidemiology (S.N.), Johns Hopkins University, Baltimore, MD.
Gordon F TomaselliFrom the Section of Cardiac Electrophsyiology (K.F., M.H., E.G.I., I.M.K., D.S., H.A., N.T., G.F.T., J.R., J.E.M., R.D.B., H.C., S.N.), Department of Biomedical Engineering (S.Z., H.A., N.T., R.D.B.), Department of Radiology (S.L.Z.), Department of Biostatistics (V.Z.), and Department of Epidemiology (S.N.), Johns Hopkins University, Baltimore, MD.
John RickardFrom the Section of Cardiac Electrophsyiology (K.F., M.H., E.G.I., I.M.K., D.S., H.A., N.T., G.F.T., J.R., J.E.M., R.D.B., H.C., S.N.), Department of Biomedical Engineering (S.Z., H.A., N.T., R.D.B.), Department of Radiology (S.L.Z.), Department of Biostatistics (V.Z.), and Department of Epidemiology (S.N.), Johns Hopkins University, Baltimore, MD.
Joseph E MarineFrom the Section of Cardiac Electrophsyiology (K.F., M.H., E.G.I., I.M.K., D.S., H.A., N.T., G.F.T., J.R., J.E.M., R.D.B., H.C., S.N.), Department of Biomedical Engineering (S.Z., H.A., N.T., R.D.B.), Department of Radiology (S.L.Z.), Department of Biostatistics (V.Z.), and Department of Epidemiology (S.N.), Johns Hopkins University, Baltimore, MD.
Ronald D BergerFrom the Section of Cardiac Electrophsyiology (K.F., M.H., E.G.I., I.M.K., D.S., H.A., N.T., G.F.T., J.R., J.E.M., R.D.B., H.C., S.N.), Department of Biomedical Engineering (S.Z., H.A., N.T., R.D.B.), Department of Radiology (S.L.Z.), Department of Biostatistics (V.Z.), and Department of Epidemiology (S.N.), Johns Hopkins University, Baltimore, MD.
Hugh CalkinsFrom the Section of Cardiac Electrophsyiology (K.F., M.H., E.G.I., I.M.K., D.S., H.A., N.T., G.F.T., J.R., J.E.M., R.D.B., H.C., S.N.), Department of Biomedical Engineering (S.Z., H.A., N.T., R.D.B.), Department of Radiology (S.L.Z.), Department of Biostatistics (V.Z.), and Department of Epidemiology (S.N.), Johns Hopkins University, Baltimore, MD.
Saman NazarianFrom the Section of Cardiac Electrophsyiology (K.F., M.H., E.G.I., I.M.K., D.S., H.A., N.T., G.F.T., J.R., J.E.M., R.D.B., H.C., S.N.), Department of Biomedical Engineering (S.Z., H.A., N.T., R.D.B.), Department of Radiology (S.L.Z.), Department of Biostatistics (V.Z.), and Department of Epidemiology (S.N.), Johns Hopkins University, Baltimore, MD. snazarian@jhmi.edu.

Funding

BIOMEDICAL ENGINEERING TRAINING PROGRAMT32GM007057 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI KANOLD, PATRICK O, KARCHIN, RACHEL · 1985 to 2023
$10.4M
Virtual Electrophysiology LaboratoryDP1HL123271 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI TRAYANOVA, NATALIA A. · 2013 to 2017
$4.0M
ANCILLARY STUDY OF SUBSTRATE AND INTERVENTION MECHANISMS FOR MALIGNANT ARRHYTHMIAR01HL116280 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI NAZARIAN, SAMAN · 2013 to 2016
$1.2M
Applications of Magnetic Resonance for Management of Ventricular TachycardiaK23HL089333 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI NAZARIAN, SAMAN · 2010 to 2014
$686k
NHLBI NIH HHS DP1 HL123271NHLBI NIH HHS K23 HL089333NHLBI NIH HHS K23HL089333NHLBI NIH HHS R01 HL116280NHLBI NIH HHS R01HL116280NIGMS NIH HHS T32 GM007057
6 · The paper itself

Abstract

backgroundPrior studies have demonstrated regional left atrial late gadolinium enhancement (LGE) heterogeneity on magnetic resonance imaging. Heterogeneity in regional conduction velocities is a critical substrate for functional reentry. We sought to examine the association between left atrial conduction velocity and LGE in patients with atrial fibrillation. METHODS AND

resultsLGE imaging and left atrial activation mapping were performed during sinus rhythm in 22 patients before pulmonary vein isolation. The locations of 1468 electroanatomic map points were registered to the corresponding anatomic sites on 469 axial LGE image planes. The local conduction velocity at each point was calculated using previously established methods. The myocardial wall thickness and image intensity ratio defined as left atrial myocardial LGE signal intensity divided by the mean left atrial blood pool intensity was calculated for each mapping site. The local conduction velocity and image intensity ratio in the left atrium (mean ± SD) were 0.98 ± 0.46 and 0.95 ± 0.26 m/s, respectively. In multivariable regression analysis, clustered by patient, and adjusting for left atrial wall thickness, conduction velocity was associated with the local image intensity ratio (0.20 m/s decrease in conduction velocity per increase in unit image intensity ratio, P<0.001).

conclusionsIn this clinical in vivo study, we demonstrate that left atrial myocardium with increased gadolinium uptake has lower local conduction velocity. Identification of such regions may facilitate the targeting of the substrate for reentrant arrhythmias.

Indexed as

Atrial Function, LeftElectrophysiologic Techniques, CardiacHeart AtriaHeart Conduction SystemMagnetic Resonance ImagingAction PotentialsAgedAtrial FibrillationContrast MediaFemaleGadolinium DTPAHumansImage Interpretation, Computer-AssistedKineticsMaleMiddle AgedContrast MediaGadolinium DTPAarrhythmias, cardiacatrial fibrillationfibrosismagnetic resonance imagingregression analysis

Identifiers

PMID26917814
PMCPMC4772170

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