Evidence map›Paper›PMID 26917794›Full record

ArticleBMJ case reports2016

Concurrent cryptococcal meningitis and disseminated tuberculosis occurring in an immunocompetent male.

Marcellin Musabende, Constance Mukabatsinda, Elisabeth D Riviello, Onyema Ogbuagu

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in BMJ case reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Marcellin MusabendeDepartment of Medicine, University Teaching Hospital of Kigali, Kigali, Rwanda.
Constance MukabatsindaDepartment of Medicine, University Teaching Hospital of Kigali, Kigali, Rwanda.
Elisabeth D RivielloDepartment of Medicine, University Teaching Hospital of Kigali, Kigali, Rwanda Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.
Onyema OgbuaguDepartment of Medicine, University Teaching Hospital of Kigali, Kigali, Rwanda Section of Infectious Diseases, Yale University School of Medicine, New Haven, Connecticut, USA.
Centre Hospitalier Universitaire de Kigali · RWHarvard University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 61-year-old man living in rural Rwanda presented with a 2-month history of fevers, headaches, dry cough, weight loss and confusion. A cerebrospinal fluid analysis revealed neutrophilic pleocytosis, yeast and a positive cryptococcal antigen (CrAg). An HIV antibody test was negative. The patient's cough worsened while on antifungal induction therapy with intravenous conventional amphotericin B and high-dose oral fluconazole. Computerised tomography (CT) scan of the chest showed extensive miliary infiltrates. Bronchoalveolar lavage revealed acid-fast bacilli on smear and a positive GeneXpert test without rifampicin resistance. The patient improved with the addition of antitubercular therapy. In this case report, we describe an unusual presentation of two opportunistic infections occurring together in an HIV-negative man with no other known immunocompromising conditions. The case highlights the fact that, in disease endemic areas, multiple disseminated infections can occur in individuals without obvious immunocompromise.

Indexed as

Antigens, FungalAntitubercular AgentsCoinfectionHumansMaleMeningitis, CryptococcalMiddle AgedTreatment OutcomeTuberculosis, MiliaryAntigens, FungalAntitubercular Agents

Identifiers

PMID26917794
PMCPMC4769440
OpenAlexW2281428060

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.