ArticleScience (New York, N.Y.)2016
Synchronous Drosophila circadian pacemakers display nonsynchronous Ca²⁺ rhythms in vivo.
Article in Science (New York, N.Y.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers.
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Who cites it
118 citing papers in PubMed, 194 citations in OpenAlex.
- Core circadian clock genes control molecular and behavioral circatidal rhythms in Parhyale hawaiensis.Current biology : CB · 2026Article
- Protocol for a saline-free surgical preparation of adult Drosophila for chronic in vivo brain imaging.STAR protocols · 2026Article
- Soma CaCurrent biology : CB · 2026Article
- Behavioral adaptation to warm conditions via Lim1-mediated acceleration of neuronal clocks.Nature neuroscience · 2026Article
- Review
- Remote and partial clocks expand the circadian neuronal network, driving widespread molecular rhythmicity inbioRxiv : the preprint server for biology · 2025Article
- Article
- A functional clock in only two dorsal clock neurons is sufficient to restore the basal circadian activity pattern ofProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Synaptic targets of circadian clock neurons influence core clock parameters.Science advances · 2025Article
- Neuropeptide dynamics coordinate layered plasticity mechanisms adaptingScience advances · 2025Article
- Desynchronized Somas and Terminals in a Morning Clock Neuron: Presynaptic CabioRxiv : the preprint server for biology · 2025Article
- Mutual coupling of neurons in the circadian master clock: What we can learn from fruit flies.Neurobiology of sleep and circadian rhythms · 2025Article
- The Never Given 2022 Pittendrigh/Aschoff Lecture: The Clock Network in the Brain-Insights From Insects.Journal of biological rhythms · 2025Article
- Synaptic Targets of Circadian Clock Neurons Influence Core Clock Parameters.bioRxiv : the preprint server for biology · 2025Article
- Transcriptome and Neuroendocrinome Responses to Environmental Stress in the Model and Pest InsectInternational journal of molecular sciences · 2025Article
- Insect circadian plasticity as a proposed target for the expression of parasite extended phenotypes.Npj biological timing and sleep · 2025Review
- Biological rhythms: Living your life, one half-day at a time.Npj biological timing and sleep · 2025Review
- Synaptic connectome of the Drosophila circadian clock.Nature communications · 2024Article
- Temperature cues are integrated in a flexible circadian neuropeptidergic feedback circuit to remodel sleep-wake patterns in flies.PLoS biology · 2024Article
- Light and dopamine impact two circadian neurons to promote morning wakefulness.Current biology : CB · 2024Article
58 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In Drosophila, molecular clocks control circadian rhythmic behavior through a network of ~150 pacemaker neurons. To explain how the network's neuronal properties encode time, we performed brainwide calcium imaging of groups of pacemaker neurons in vivo for 24 hours. Pacemakers exhibited daily rhythmic changes in intracellular Ca(2+) that were entrained by environmental cues and timed by molecular clocks. However, these rhythms were not synchronous, as each group exhibited its own phase of activation. Ca(2+) rhythms displayed by pacemaker groups that were associated with the morning or evening locomotor activities occurred ~4 hours before their respective behaviors. Loss of the receptor for the neuropeptide PDF promoted synchrony of Ca(2+) waves. Thus, neuropeptide modulation is required to sequentially time outputs from a network of synchronous molecular pacemakers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.