ArticleJournal of applied physiology (Bethesda, Md. : 1985)2016
Chronic intermittent hypoxia alters ventilatory and metabolic responses to acute hypoxia in rats.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Effects of losartan and allopurinol on cardiorespiratory regulation in obstructive sleep apnoea.Experimental physiology · 2018Trial
- Altered control of breathing in a rat model of allergic lower airway inflammation.Journal of neurophysiology · 2024Article
- Commonalities and differences in carotid body dysfunction in hypertension and heart failure.The Journal of physiology · 2023Article
- CORP: Sources and degrees of variability in whole animal intermittent hypoxia experiments.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Metabolic responses to intermittent hypoxia are regulated by sex and estradiol in mice.American journal of physiology. Endocrinology and metabolism · 2021Article
- β-Adrenoceptor blockade prevents carotid body hyperactivity and elevated vascular sympathetic nerve density induced by chronic intermittent hypoxia.Pflugers Archiv : European journal of physiology · 2021Article
- Obstructive Sleep Apnea and Systemic Hypertension: Gut Dysbiosis as the Mediator?Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2019Review
- Chronic intermittent hypoxia enhances disease progression in myeloma-resistant mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Chronic intermittent hypoxia disrupts cardiorespiratory homeostasis and gut microbiota composition in adult male guinea-pigs.EBioMedicine · 2018Article
- Effect of Chronic Intermittent Hypoxia on Angiotensin II Receptors in the Central Nervous System.Clinical and experimental hypertension (New York, N.Y. : 1993) · 2018Article
- Effect of Gender on Chronic Intermittent HypoxicFrontiers in physiology · 2018Article
- Respiratory muscle dysfunction in animal models of hypoxic disease: antioxidant therapy goes from strength to strength.Hypoxia (Auckland, N.Z.) · 2017Review
- Oxidative stress augments chemoreflex sensitivity in rats exposed to chronic intermittent hypoxia.Respiratory physiology & neurobiology · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
We determined the effects of chronic exposure to intermittent hypoxia (CIH) on chemoreflex control of ventilation in conscious animals. Adult male Sprague-Dawley rats were exposed to CIH [nadir oxygen saturation (SpO2), 75%; 15 events/h; 10 h/day] or normoxia (NORM) for 21 days. We assessed the following responses to acute, graded hypoxia before and after exposures: ventilation (V̇e, via barometric plethysmography), V̇o2 and V̇co2 (analysis of expired air), heart rate (HR), and SpO2 (pulse oximetry via neck collar). We quantified hypoxia-induced chemoreceptor sensitivity by calculating the stimulus-response relationship between SpO2 and the ventilatory equivalent for V̇co2 (linear regression). An additional aim was to determine whether CIH causes proliferation of carotid body glomus cells (using bromodeoxyuridine). CIH exposure increased the slope of the V̇e/V̇co2/SpO2 relationship and caused hyperventilation in normoxia. Bromodeoxyuridine staining was comparable in CIH and NORM. Thus our CIH paradigm augmented hypoxic chemosensitivity without causing glomus cell proliferation.
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Registered trials
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