ArticleThe Journal of infectious diseases2016
Vancomycin Treatment Alters Humoral Immunity and Intestinal Microbiota in an Aged Mouse Model of Clostridium difficile Infection.
Article in The Journal of infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- Adenosine deaminase co-immunization reverses age-associated immunosenescence by restoring germinal center T follicular helper cell function.bioRxiv : the preprint server for biology · 2026Article
- Clostridioides difficile toxin A and toxin B inhibit toxin-specific adaptive immune responses through glucosyltransferase-dependent activity.Mucosal immunology · 2025Article
- IL-33 protects from recurrent C. difficile infection by restoration of humoral immunity.The Journal of clinical investigation · 2025Article
- Early life microbiome disbalance impacts neuroendocrine outcomes in pre-pubertal mice in a sexually dimorphic manner.Frontiers in microbiology · 2025Article
- IL-33 protects from recurrentbioRxiv : the preprint server for biology · 2024Article
- Antibiotic-induced gut microbiota disruption promotes vascular calcification by reducing short-chain fatty acid acetate.Molecular medicine (Cambridge, Mass.) · 2024Article
- Article
- Correlating Antibiotic-Induced Dysbiosis toACS infectious diseases · 2023Article
- Long-term antibiotic exposure promotes mortality after systemic fungal infection by driving lymphocyte dysfunction and systemic escape of commensal bacteria.Cell host & microbe · 2022Article
- Faecal microbiota transplantation for Clostridioides difficile: mechanisms and pharmacology.Nature reviews. Gastroenterology & hepatology · 2021Review
- Aging Dampens the Intestinal Innate Immune Response during Severe Clostridioides difficile Infection and Is Associated with Altered Cytokine Levels and Granulocyte Mobilization.Infection and immunity · 2020Article
- Persistent Systemic Microbial Translocation, Inflammation, and Intestinal Damage DuringOpen forum infectious diseases · 2020Article
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- Human Breast-Milk Feeding Enhances the Humoral and Cell-Mediated Immune Response in Neonatal Piglets.The Journal of nutrition · 2018Article
- Disruption of maternal gut microbiota during gestation alters offspring microbiota and immunity.Microbiome · 2018Article
- Clostridium difficile, Aging, and the Gut: Can Microbiome Rejuvenation Keep Us Young and Healthy?The Journal of infectious diseases · 2018Article
- Innate Immune Response and Outcome of Clostridium difficile Infection Are Dependent on Fecal Bacterial Composition in the Aged Host.The Journal of infectious diseases · 2018Article
- Intestinal Microbiota at Engraftment Influence Acute Graft-Versus-Host DiseaseFrontiers in immunology · 2018Article
- Collateral damage during antibiotic treatment of C. difficile infection in the aged host: Insights into why recurrent disease happens.Gut microbes · 2017Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe elderly host is highly susceptible to severe disease and treatment failure in Clostridium difficile infection (CDI). We investigated how treatment with vancomycin in the aged host influences systemic and intestinal humoral responses and select intestinal microbiota.
methodsYoung (age, 2 months) and aged (age, 18 months) C57BL/6 mice were infected with VPI 10463 after exposure to broad-spectrum antibiotics. Vancomycin was given 24 hours after infection, and treatment was continued for 5 days. At select time points, specimens of serum and intestinal tissue and contents were collected for histopathologic analysis, to measure antibody levels and the pathogen burden, and to determine the presence and levels of select intestinal microbiota and C. difficile toxin.
resultsLevels of disease severity, relapse, and mortality were increased, and recovery from infection was slower in aged mice compared to young mice. Serum levels of immunoglobulin M, immunoglobulin A, and immunoglobulin G against C. difficile toxin A were depressed in aged mice, and vancomycin treatment reduced antibody responses in both age groups. While baseline levels of total bacterial load, Bacteroidetes, Firmicutes, and Enterobacteriaceae were mostly similar, aged mice had a significant change in the Firmicutes to Bacteroidetes ratio with vancomycin treatment.
conclusionsVancomycin treatment decreases the systemic humoral response to CDI. Increased mortality from and recurrence of CDI in the aged host are associated with an impaired humoral response and a greater susceptibility to vancomycin-induced alteration of intestinal microbiota.
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Registered trials
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