ArticleBMJ open2016
Association between traffic-related air pollution and asthma in preschool children in a national Japanese nested case-control study.
Article in BMJ open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Impacts from air pollution on respiratory disease outcomes: a meta-analysis.Frontiers in public health · 2024Pooled it
- Risk factors of asthma in the Asian population: a systematic review and meta-analysis.Journal of physiological anthropology · 2021Pooled it
- Traffic-Related Air Pollution and Childhood Asthma: Recent Advances and Remaining Gaps in the Exposure Assessment Methods.International journal of environmental research and public health · 2017Pooled it
- Epidemiological studies on the health impact of air pollution in Japan: their contribution to the improvement of ambient air quality.Environmental health and preventive medicine · 2025Review
- Does residential address-based exposure assessment for outdoor air pollution lead to bias in epidemiological studies?Environmental health : a global access science source · 2024Review
- Global Considerations in Asthma Treatment: Management in Low Resource Settings.Advances in experimental medicine and biology · 2023Article
- Risk Factors Affecting Development and Persistence of Preschool Wheezing: Consensus Document of the Emilia-Romagna Asthma (ERA) Study Group.Journal of clinical medicine · 2022Article
- Concentrations of indoor gaseous air pollutants and risk factors associated with childhood asthma in Benin City, Nigeria.Environmental monitoring and assessment · 2022Article
- S3 guideline Allergy Prevention.Allergologie select · 2022Article
- Outdoor air pollution and the onset and exacerbation of asthma.Chronic diseases and translational medicine · 2021Review
- Annual changes in the prevalence of asthma may be related to air pollution in Fukuoka: 29 years of observation.ERJ open research · 2020Article
- Early life exposure to air pollution and incidence of childhood asthma, allergic rhinitis and eczema.The European respiratory journal · 2020Article
- Coal burning-derived SOEnvironmental health and preventive medicine · 2019Article
- Correlations of severity of asthma in children with body mass index, adiponectin and leptin.Journal of clinical laboratory analysis · 2019Article
- Pediatric pulmonology year in review 2016: Part 2.Pediatric pulmonology · 2017Review
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThere has been little study on the effect of traffic-related air pollution on the incidence and persistence of asthma in preschool children. We evaluated the association of exposure to traffic-related air pollution with the incidence/persistence of asthma during the first 3 years of life using a population-based study.
methodsA baseline survey was conducted in 1½-year-old children (n=63,266). A follow-up survey at 3 years of age (n=43,343) identified new-onset asthma cases (n=853) and persistence of asthma (n=214). In the prevalence/persistence study, the outdoor concentrations of nitrogen oxides (NOx) and elemental carbon (EC) at home during the first 1½ years of life were estimated by a dispersion model. In the nested case-control study, which regarded incidence of asthma as cases, the personal exposure levels were estimated by dispersion model including time-activity pattern.
resultsThere was no statistically significant association between the incidence of asthma between age 1½ and 3 years and personal exposure levels to NOx nor EC. However, the persistence of asthmatic symptoms (between 1½ and 3 ears) was significantly associated with outdoor concentrations of NOx. ORs for the persistence of asthmatic symptoms were 6.02 (95% CI 1.51 to 23.92) for the comparison between the upper 5th and lower 25th centiles of NOx.
conclusionsWhile no statistically significant association was observed for the incidence of asthma, the persistence of asthmatic symptoms in preschool children was significantly associated with traffic-related air pollution. This supports its importance as a risk factor in childhood airway disease.
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Registered trials
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