Evidence map›Paper›PMID 26916611›Full record

Trial reportJournal of geriatric oncology2016

Novel physical activity interventions for older patients with prostate cancer on hormone therapy: A pilot randomized study.

Saleha Sajid, William Dale, Karen Mustian, Ashwin Kotwal, Charles Heckler, Michelle Porto, Chunkit Fung, Supriya G Mohile

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of geriatric oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 19 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 19 pooled it
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 19 syntheses or guidelines pooled it, 68 citations in OpenAlex.

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  6. Inclusivity in prostate cancer and exercise research: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
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  11. The effectiveness of lifestyle interventions to reduce side effects of androgen deprivation therapy for men with prostate cancer: a systematic review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2020
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Saleha SajidDepartment of Medicine, Section of Geriatrics & Palliative Medicine, and Hematology/Oncology, University of Chicago, Chicago, IL, USA. Electronic address: salehasajid@gmail.com.
William DaleDepartment of Medicine, Section of Geriatrics & Palliative Medicine, and Hematology/Oncology, University of Chicago, Chicago, IL, USA. Electronic address: wdale@medicine.bsd.uchicago.edu.
Karen MustianDepartment of Medicine, James Wilmot Cancer Institute, University of Rochester, Rochester, NY, USA. Electronic address: Karen_mustian@urmc.rochester.edu.
Ashwin KotwalDepartment of Medicine, Section of Geriatrics & Palliative Medicine, and Hematology/Oncology, University of Chicago, Chicago, IL, USA. Electronic address: akotwal@uchicago.edu.
Charles HecklerDepartment of Medicine, James Wilmot Cancer Institute, University of Rochester, Rochester, NY, USA.
Michelle PortoDepartment of Medicine, James Wilmot Cancer Institute, University of Rochester, Rochester, NY, USA.
Chunkit FungDepartment of Medicine, James Wilmot Cancer Institute, University of Rochester, Rochester, NY, USA. Electronic address: chunkit_fung@urmc.rochester.edu.
Supriya G MohileDepartment of Medicine, James Wilmot Cancer Institute, University of Rochester, Rochester, NY, USA. Electronic address: Supriya_mohile@urmc.rochester.edu.
University of Rochester · USUniversity of Chicago · US

Funding

URCC NCORP Research BaseUG1CA189961 · NCI · UNIVERSITY OF ROCHESTER · PI Michelle C Janelsins, KAREN M. MUSTIAN · 2014 to 2026
$67.7M
Cancer Control Research Training Curriculum (R25T)R25CA102618 · NCI · UNIVERSITY OF ROCHESTER · PI JANELSINS, MICHELLE C, MORROW, GARY R · 2004 to 2018
$6.7M
Reducing Chemotherapy Toxicity in Older AdultsR01CA177592 · NCI · UNIVERSITY OF ROCHESTER · PI MOHILE, SUPRIYA G. · 2013 to 2018
$3.0M
Geriatric Assessment - Driven Interventions for Older Cancer PatientsR03AG042342 · NIA · UNIVERSITY OF ROCHESTER · PI MOHILE, SUPRIYA G. · 2012 to 2013
$167k
NCI NIH HHS R01 CA177592NCI NIH HHS R25 CA102618NCI NIH HHS UG1 CA18961NCI NIH HHS UG1 CA189961NIA NIH HHS R03 AG042342
6 · The paper itself

Abstract

backgroundAndrogen deprivation therapy (ADT) can decrease the physical performance (PP) of older men with prostate cancer (PC).

methodsWe conducted a three-arm randomized pilot study (n=19) comparing a home-based walking and resistance intervention (EXCAP) and a technology-mediated walking and resistance intervention using Wii-Fit to a usual-care arm in men ≥70 years with PC receiving ADT. The intervention lasted for 6 weeks, with follow-up at 12 weeks. The primary pre-specified outcome was change in Short Physical Performance Battery (SPPB) score. Mixed effects regression models were used to assess change in outcomes over time.

resultsMean participant age was 70 years (range: 67-93). Eight patients were randomized to the Wii-Fit arm, 6 to the EXCAP arm, and 5 to the usual-care arm. SPPB scores remained nearly constant in the usual-care arm (β=-0.12; p=0.79), while individuals in the EXCAP arm had on average a 1.2 point increase at each follow-up (β=1.20; 95% CI: 0.36, 2.06). The Wii-fit arm had a non-significant increase in SPPB score over time relative to usual-care (β=0.32; 95% CI -0.43, 1.06; p=0.46). Individuals in the EXCAP arm had an increase in steps per day over time compared to the usual-care arm (p-value=0.006); the EXCAP arm had an increase of 2720 steps (95% CI: 1313, 4128) while the usual-care arm had an increase of 97 steps (95% CI: -1140, 1333). Participants in the Wii-Fit arm had an increase of 1020 steps (95% CI: -474, 1238, p=0.710). Other outcomes (i.e., handgrip strength, lean muscle mass, and chest press repetitions) were not statistically significant.

conclusionsA home-based aerobic and resistance exercise program, EXCAP, shows promise for improving PP in older men with PC on ADT.

Indexed as

AgedAged, 80 and overAndrogen AntagonistsExerciseExercise TherapyHand StrengthHumansLinear ModelsMaleMuscle StrengthPilot ProjectsProstatic NeoplasmsWalkingAndrogen AntagonistsAndrogen deprivation therapyElderlyHome-based exercise interventionsOlder adultsProstate cancerWii-Fit

Identifiers

PMID26916611
PMCPMC4818675
OpenAlexW2278910754

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.