ArticleScientific reports2016
Human colorectal mucosal microbiota correlates with its host niche physiology revealed by endomicroscopy.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Sequential laxative-probiotic usage for treatment of irritable bowel syndrome: a novel method inspired by mathematical modelling of the microbiome.Scientific reports · 2020Trial
- The effect of Clostridium butyricum on symptoms and fecal microbiota in diarrhea-dominant irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial.Scientific reports · 2018Trial
- Multi-level aggregation analysis of microbiome composition and host gene expression reveals associations with systemic and local immunity.Microbiology spectrum · 2026Article
- Impact of gut microbiome on outcomes following endoscopic interventions in gastrointestinal disease.World journal of gastrointestinal endoscopy · 2025Article
- Gut microbiota alterations in golden snub-nosed monkeys during food shortage and parturition-nursing periods.Frontiers in microbiology · 2025Article
- Low Reproductivity of Giant Pandas May Be Associated with Increased VaginalMicroorganisms · 2024Article
- Effect of pH-sensitive nanoparticles on inhibiting oral biofilms.Drug delivery · 2022Article
- Liposome Delivery of Nucleic Acids in Bacteria: TowardACS infectious diseases · 2022Article
- The Plaque Microbiota Community of Giant Panda (Frontiers in cellular and infection microbiology · 2022Article
- The human oral - nasopharynx microbiome as a risk screening tool for nasopharyngeal carcinoma.Frontiers in cellular and infection microbiology · 2022Article
- Saccharomyces boulardii improves the behaviour and emotions of spastic cerebral palsy rats through the gut-brain axis pathway.BMC neuroscience · 2021Article
- Metagenomic Analysis Reveals New Microbiota Related to Fiber Digestion in Pigs.Frontiers in microbiology · 2021Article
- Perturbation of the gut microbiome by Prevotella spp. enhances host susceptibility to mucosal inflammation.Mucosal immunology · 2021Article
- The Clinical Potential of Oral Microbiota as a Screening Tool for Oral Squamous Cell Carcinomas.Frontiers in cellular and infection microbiology · 2021Article
- Faecal microbiota transplantation from metabolically compromised human donors accelerates osteoarthritis in mice.Annals of the rheumatic diseases · 2020Article
- Oral bacteria colonize and compete with gut microbiota in gnotobiotic mice.International journal of oral science · 2019Article
- Research on oral microbiota of monozygotic twins with discordant caries experience - in vitro and in vivo study.Scientific reports · 2018Article
- Anti-Bacteria and Microecosystem-Regulating Effects of Dental Implant Coated with Dimethylaminododecyl Methacrylate.Molecules (Basel, Switzerland) · 2017Article
- Confocal Laser Endomicroscopy in the Management of IBD: Clearly Superior?Digestive diseases and sciences · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human gut microbiota plays a pivotal role in the maintenance of health, but how the microbiota interacts with the host at the colorectal mucosa is poorly understood. We proposed that confocal laser endomicroscopy (CLE) might help to untangle this relationship by providing in vivo physiological information of the mucosa. We used CLE to evaluate the in vivo physiology of human colorectal mucosa, and the mucosal microbiota was quantified using 16 s rDNA pyrosequencing. The human mucosal microbiota agglomerated to three major clusters dominated by Prevotella, Bacteroides and Lactococcus. The mucosal microbiota clusters did not significantly correlate with the disease status or biopsy sites but closely correlated with the mucosal niche physiology, which was non-invasively revealed by CLE. Inflammation tilted two subnetworks within the mucosal microbiota. Infiltration of inflammatory cells significantly correlated with multiple components in the predicted metagenome, such as the VirD2 component of the type IV secretory pathway. Our data suggest that a close correlation exists between the mucosal microbiota and the colorectal mucosal physiology, and CLE is a clinically available tool that can be used to facilitate the study of the in vivo correlation between colorectal mucosal physiology and the mucosal microbiota.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.