ArticleActa neuropathologica communications2016
A general homeostatic principle following lesion induced dendritic remodeling.
Article in Acta neuropathologica communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Spatiotemporal patterns of gene expression changes in the mouse dentate gyrus following entorhinal denervation.Frontiers in molecular neuroscience · 2026Article
- Regional Microglial Response in Entorhino-Hippocampal Slice Cultures to Schaffer Collateral Lesion and Metalloproteinases Modulation.International journal of molecular sciences · 2024Article
- A biologically inspired repair mechanism for neuronal reconstructions with a focus on human dendrites.PLoS computational biology · 2024Article
- Synaptopodin Regulates Denervation-Induced Plasticity at Hippocampal Mossy Fiber Synapses.Cells · 2024Article
- Dendritic normalisation improves learning in sparsely connected artificial neural networks.PLoS computational biology · 2021Article
- Orexin-A Attenuates Inflammatory Responses in Lipopolysaccharide-Induced Neural Stem Cells by Regulating NF-KB and Phosphorylation of MAPK/P38/Erk Pathways.Journal of inflammation research · 2021Article
- NeuroPath2Path: Classification and elastic morphing between neuronal arbors using path-wise similarity.Neuroinformatics · 2020Article
- Quantifying How Staining Methods Bias Measurements of Neuron Morphologies.Frontiers in neuroinformatics · 2019Article
- Article
- Universal features of dendrites through centripetal branch ordering.PLoS computational biology · 2017Article
- Sphingosine-1-phosphate receptor inhibition prevents denervation-induced dendritic atrophy.Acta neuropathologica communications · 2016Article
- Opposing Effects of Neuronal Activity on Structural Plasticity.Frontiers in neuroanatomy · 2016Review
- A Novel Form of Compensation in the Tg2576 Amyloid Mouse Model of Alzheimer's Disease.Frontiers in cellular neuroscience · 2016Article
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5 authors.
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Abstract
introductionNeuronal death and subsequent denervation of target areas are hallmarks of many neurological disorders. Denervated neurons lose part of their dendritic tree, and are considered "atrophic", i.e. pathologically altered and damaged. The functional consequences of this phenomenon are poorly understood.
resultsUsing computational modelling of 3D-reconstructed granule cells we show that denervation-induced dendritic atrophy also subserves homeostatic functions: By shortening their dendritic tree, granule cells compensate for the loss of inputs by a precise adjustment of excitability. As a consequence, surviving afferents are able to activate the cells, thereby allowing information to flow again through the denervated area. In addition, action potentials backpropagating from the soma to the synapses are enhanced specifically in reorganized portions of the dendritic arbor, resulting in their increased synaptic plasticity. These two observations generalize to any given dendritic tree undergoing structural changes.
conclusionsStructural homeostatic plasticity, i.e. homeostatic dendritic remodeling, is operating in long-term denervated neurons to achieve functional homeostasis.
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