Evidence map›Paper›PMID 26916469›Full record

ArticleSuicide & life-threatening behavior2016

Anorexia Nervosa, Major Depression, and Suicide Attempts: Shared Genetic Factors.

Laura M Thornton, Elisabeth Welch, Melissa A Munn-Chernoff, Paul Lichtenstein, Cynthia M Bulik

Abstract readTwin Study
In one paragraph

Article in Suicide & life-threatening behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Genomic links between symptoms of eating disorders and suicidal ideation.European psychiatry : the journal of the Association of European Psychiatrists · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Validity and utility of Hierarchical Taxonomy of Psychopathology (HiTOP): III. Emotional dysfunction superspectrum.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2022
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Laura M ThorntonDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Elisabeth WelchDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Melissa A Munn-ChernoffDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Paul LichtensteinDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Cynthia M BulikDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. cbulik@med.unc.edu.

Funding

GENETIC &ENVIRONMENT DETERMINANTS OF SMOKING CESSATIONR01CA085739 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI SULLIVAN, PATRICK F · 2001 to 2006
$3.1M
Postdoctoral Research Training in Eating DisordersT32MH076694 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BULIK, CYNTHIA M · 2007 to 2016
$1.8M
Microarrays &Proteomics in MZ Twins Discordant for CFSR01AI056014 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SULLIVAN, PATRICK F · 2004 to 2006
$1.2M
NCI NIH HHS R01 CA085739NIAID NIH HHS R01 AI056014NIMH NIH HHS T32 MH076694
6 · The paper itself

Abstract

The extent to which genetic and environmental factors influenced anorexia nervosa (AN), major depressive disorder (MDD), and suicide attempts (SA) were evaluated. Participants were 6,899 women from the Swedish Twin Study of Adults: Genes and Environment. A Cholesky decomposition assessed independent and overlapping genetic and environmental contributions to AN, MDD, and SA. Genetic factors accounted for a substantial amount of liability to all three traits; unique environmental factors accounted for most of the remaining liability. Shared genetic factors may underlie the coexpression of these traits. Results underscore the importance of assessing for signs of suicide among individuals with AN.

Indexed as

Anorexia NervosaMajor Depressive DisorderSuicide, AttemptedAdultComorbidityFemaleGene-Environment InteractionHumansMiddle AgedPhenotypePrevalencePsychiatric Status Rating ScalesRisk FactorsStatistics as TopicSweden

Identifiers

PMID26916469
PMCPMC4996767

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.