Evidence map›Paper›PMID 26916454›Full record

SynthesisHeart & lung : the journal of critical care

Effects of exercise on c-reactive protein in healthy patients and in patients with heart disease: A meta-analysis.

Tracy L Hammonds, Emily C Gathright, Carly M Goldstein, Marc S Penn, Joel W Hughes

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Heart & lung : the journal of critical care. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
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  6. Trial
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  8. Review
  9. Association between serum high-sensitivity C-reactive protein levels and migraine: a REFORM study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tracy L HammondsKent State University, P.O. Box 5190, Kent, OH, USA; Cardiovascular Institute, Summa Health System, 95 Arch St, Akron, OH, USA.
Emily C GathrightKent State University, P.O. Box 5190, Kent, OH, USA.
Carly M GoldsteinKent State University, P.O. Box 5190, Kent, OH, USA; Cardiovascular Institute, Summa Health System, 95 Arch St, Akron, OH, USA; Warren Alpert Medical School of Brown University, Providence, RI, USA.
Marc S PennCardiovascular Institute, Summa Health System, 95 Arch St, Akron, OH, USA; Department of Integrated Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, USA.
Joel W HughesKent State University, P.O. Box 5190, Kent, OH, USA; Cardiovascular Institute, Summa Health System, 95 Arch St, Akron, OH, USA. Electronic address: jhughes1@kent.edu.

Funding

Training in Behavioral & Preventive MedicineT32HL076134 · NHLBI · MIRIAM HOSPITAL · PI John Graham Thomas · 2006 to 2026
$5.7M
NHLBI NIH HHS T32 HL076134
6 · The paper itself

Abstract

Decreases in circulating hsCRP have been associated with increased physical activity and exercise training, although the ability of exercise interventions to reduce hsCRP and which individuals benefit the most remains unclear. This meta-analysis evaluates the ability of exercise to reduce hsCRP levels in healthy individuals and in individuals with heart disease. A systematic review and meta-analysis was conducted that included exercise interventions trials from 1995 to 2012. Forty-three studies were included in the final analysis for a total of 3575 participants. Exercise interventions significantly reduced hsCRP (standardized mean difference -0.53 mg/L; 95% CI, -0.74 to -0.33). Results of sub-analysis revealed no significant difference in reductions in hsCRP between healthy adults and those with heart disease (p = .20). Heterogeneity between studies could not be attributed to age, gender, intervention length, intervention type, or inclusion of diet modification. Exercise interventions reduced hsCRP levels in adults irrespective of the presence of heart disease.​.

Indexed as

BiomarkersC-Reactive ProteinExerciseExercise TherapyHeart DiseasesHumansBiomarkersC-Reactive ProteinBiological marker c-reactive proteinCoronary diseaseExerciseHeart diseaseInflammation

Identifiers

PMID26916454
PMCPMC5873310

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.