ArticleBrain connectivity2016
Interhemispheric Dorsolateral Prefrontal Cortex Connectivity is Associated with Individual Differences in Pain Sensitivity in Healthy Controls.
Article in Brain connectivity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Utility of Repetitive Transcranial Magnetic Stimulation for Chronic Daily Headache Prophylaxis: A Systematic Review and Meta-Analysis.Current pain and headache reports · 2024Pooled it
- fMRI findings in MTBI patients with headaches following rTMS.Scientific reports · 2021Trial
- Repetitive transcranial magnetic stimulation in chronic tension-type headache: A pilot study.The Indian journal of medical research · 2019Trial
- Trial
- Dorsolateral prefrontal cortex hemispheric asymmetry and chronic low back pain at 8-year follow-up in community-dwelling older adults.GeroScience · 2026Article
- Individual differences in conditioned pain modulation are associated with alpha oscillations.Pain · 2026Article
- Exploring the influence of synaptic density and anxiety on pain perception: evidence from a [11C]UCB-J positron emission tomography imaging study.The international journal of neuropsychopharmacology · 2025Article
- Chronic pain is associated with greater brain entropy in the prefrontal cortex.The journal of pain · 2025Article
- Current source density and functional connectivity extracted from resting-state electroencephalography as biomarkers for chronic low back pain.Pain reports · 2025Article
- Disruptions in cortical circuit connectivity distinguish widespread hyperalgesia from localized pain.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Critical Windows: Exploring the Association Between Perinatal Trauma, Epigenetics, and Chronic Pain.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
- Targeting Prefrontal Cortex Dysfunction in Pain.The Journal of pharmacology and experimental therapeutics · 2024Review
- Graph theory analysis reveals an assortative pain network vulnerable to attacks.Scientific reports · 2023Article
- Anodal transcranial direct current stimulation over the right primary somatosensory cortex increases cough reflex sensitivity: a pilot randomised controlled crossover trial.ERJ open research · 2023Article
- Article
- Dissociation between individual differences in self-reported pain intensity and underlying fMRI brain activation.Nature communications · 2022Article
- Aberrant resting-state regional activity in patients with postpartum depression.Frontiers in human neuroscience · 2022Article
- The influence of social signals on the self-experience of pain: A neuroimaging review.Frontiers in neurology · 2022Review
- Supraspinal nociceptive networks in neuropathic pain after spinal cord injury.Human brain mapping · 2021Article
- A lateralized model of the pain-depression dyad.Neuroscience and biobehavioral reviews · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The dorsolateral prefrontal cortex (DLPFC) is implicated in pain modulation through multiple psychological processes. Recent noninvasive brain stimulation studies suggest that interhemispheric DLPFC connectivity influences pain tolerance and discomfort by altering interhemispheric inhibition. The structure and role of interhemispheric DLPFC connectivity in pain processing have not been investigated. The present study used dynamic causal modeling (DCM) for fMRI to investigate transcallosal DLPFC connectivity during painful stimulation in healthy volunteers. DCM parameters were used to predict individual differences in sensitivity to noxious heat stimuli. Bayesian model selection results indicated that influences among the right DLPFC (rDLPFC) and left DLPFC (lDLPFC) are modulated during painful stimuli. Regression analyses revealed that greater rDLPFC→lDLPFC couplings were associated with higher suprathreshold pain temperatures. These results highlight the role of interhemispheric connectivity in pain modulation and support the preferential role of the right hemisphere in pain processing. Knowledge of these mechanisms may improve understanding of abnormal pain modulation in chronic pain populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.