ArticleBrain, behavior, and immunity2016
Emotional acceptance, inflammation, and sickness symptoms across the first two years following breast cancer diagnosis.
Article in Brain, behavior, and immunity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Targeting emotional regulation using an Internet-delivered psychological intervention for cancer survivors: A randomized controlled trial.British journal of health psychology · 2023Trial
- Positive affect and inflammation in women with breast cancer: A systematic review.Brain, behavior, & immunity - health · 2026Review
- Negative affect and peripheral inflammation: The role of cognitive reappraisal and expressive suppression.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026Article
- Emotion regulation as a protective factor in the association between stress and inflammation in older adults.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2025Article
- Differences in Emotional Awareness Moderate Cytokine-Symptom Associations Among Breast Cancer Survivors.Brain, behavior, and immunity · 2025Article
- Determinants of Demoralization Syndrome and Social Support Among Patients with Breast Cancer: A Cross-Sectional Study.Journal of multidisciplinary healthcare · 2025Article
- Association of markers of inflammation on attention and neurobehavioral outcomes in survivors of childhood acute lymphoblastic leukemia.Frontiers in oncology · 2023Article
- The role of emotion processing in art therapy (REPAT) intervention protocol.Frontiers in psychology · 2023Article
- Values and their relationship with emotion processing and physical and psychological symptoms among Jewish and Arab breast cancer survivors.Frontiers in psychology · 2023Article
- Virtual reality for the promotion of interoception awareness and body image in breast cancer survivors: a study protocol.Frontiers in psychology · 2023Article
- Night shift schedule alters endogenous regulation of circulating cytokines.Neurobiology of sleep and circadian rhythms · 2021Article
- Transitions in coping profiles after breast cancer diagnosis: implications for depressive and physical symptoms.Journal of behavioral medicine · 2021Article
- Protocol for the REPAT study: role of emotional processing in art therapy for breast cancer palliative care patients.BMJ open · 2020Article
- Scientific reports concerning the impact of interleukin 4, interleukin 10 and transforming growth factor β on cancer cells.Central-European journal of immunology · 2019Review
- Acceptance, social support, benefit-finding, and depression in women with gynecological cancer.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2018Article
- Physician Empathy Interacts with Breaking Bad News in Predicting Lung Cancer and Pleural Mesothelioma Patient Survival: Timing May Be Crucial.Journal of clinical medicine · 2018Article
- The High Costs of Low-Grade Inflammation: Persistent Fatigue as a Consequence of Reduced Cellular-Energy Availability and Non-adaptive Energy Expenditure.Frontiers in behavioral neuroscience · 2018Review
- Mechanisms of Neurotoxic Symptoms as a Result of Breast Cancer and Its Treatment: Considerations on the Contribution of Stress, Inflammation, and Cellular Bioenergetics.Current breast cancer reports · 2017Review
- Emotions and Emotion Regulation in Breast Cancer Survivorship.Healthcare (Basel, Switzerland) · 2016Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
purposeBreast cancer diagnosis and treatment are associated with increased inflammatory activity, which can induce sickness symptoms. We examined whether emotional acceptance moderates the association between proinflammatory cytokines and self-reported sickness symptoms in women recently diagnosed with breast cancer.
methodsWomen (N=136) diagnosed with stage 0-III breast cancer within the previous 6months provided plasma samples and completed the FACT: Physical Well-Being Scale, as well as the Acceptance of Emotion Scale every 3months for 2years. At each time point, we quantified interleukin (IL)-6, IL-8, IL-10, and tumor necrosis factor (TNF)-α using a high sensitivity multiplex assay.
resultsHigher within-subject mean TNF-α across all time-points predicted higher mean sickness symptoms. At individual time-points, higher IL-6 and IL-8 levels were associated with higher sickness symptoms. Mean emotional acceptance across all time-points moderated the relationship between mean IL-8 and sickness symptoms, with sickness symptoms remaining persistently high in women with low emotional acceptance even when IL-8 levels were low. At individual time-points, emotional acceptance positively moderated the correlations of IL-8 and TNF-α with sickness symptoms, such that the associations between higher levels of these proinflammatory cytokines and higher sickness symptoms were attenuated when emotional acceptance was high.
conclusionEmotional acceptance was shown for the first time to moderate the associations of cytokines with sickness symptoms in breast cancer patients over time following diagnosis and treatment. The association between emotional acceptance and sickness symptoms was significantly different from zero but relatively small in comparison to the range of sickness symptoms. Results suggest that targeting emotion regulation may help to break the cycle between inflammation and sickness symptoms in women with breast cancer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.