ArticleGenes, brain, and behavior2016
Alcohol resistance in Drosophila is modulated by the Toll innate immune pathway.
Article in Genes, brain, and behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- The non-nuclear DifB NF-κB isoform affects courtship, circadian, and locomotor behavior in adultFrontiers in behavioral neuroscience · 2025Article
- The NFκB Dif is required for behavioral and molecular correlates of sleep homeostasis in Drosophila.Sleep · 2024Article
- TBI and Tau Loss of Function Both Affect Naïve Ethanol Sensitivity inInternational journal of molecular sciences · 2024Article
- Review
- Article
- A Non-Nuclear NF-κB Modulates Alcohol Sensitivity But Not Immunity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Microbiome-by-ethanol interactions impact Drosophila melanogaster fitness, physiology, and behavior.iScience · 2022Article
- Yeast volatiles double starvation survival inScience advances · 2021Article
- Normal Ethanol Sensitivity and Rapid Tolerance Require the G Protein Receptor Kinase 2 in Ellipsoid Body Neurons in Drosophila.Alcoholism, clinical and experimental research · 2020Article
- F654A and K558Q Mutations in NMDA Receptor 1 Affect Ethanol-Induced Behaviors in Drosophila.Alcoholism, clinical and experimental research · 2019Article
- Studying alcohol use disorder using Drosophila melanogaster in the era of 'Big Data'.Behavioral and brain functions : BBF · 2019Review
- Insights from intoxicated Drosophila.Alcohol (Fayetteville, N.Y.) · 2019Review
- Dynamic changes in gene expression and alternative splicing mediate the response to acute alcohol exposure in Drosophila melanogaster.Heredity · 2018Article
- Mechanisms Underlying the Risk to Develop Drug Addiction, Insights From Studies inFrontiers in physiology · 2018Review
- Genetics and genomics of alcohol responses in Drosophila.Neuropharmacology · 2017Review
- Ethanol Consumption in Mice Lacking CD14, TLR2, TLR4, or MyD88.Alcoholism, clinical and experimental research · 2017Article
- Nuclear Factor-Kappa B and Alzheimer Disease, Unifying Genetic and Environmental Risk Factors from Cell to Humans.Frontiers in immunology · 2017Review
- Alcohol-Induced Neuroadaptation Is Orchestrated by the Histone Acetyltransferase CBP.Frontiers in molecular neuroscience · 2017Article
- The neuroimmune transcriptome and alcohol dependence: potential for targeted therapies.Pharmacogenomics · 2016Review
- Immediate-early alcohol-responsive miRNA expression in Drosophila.Journal of neurogeneticsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
A growing body of evidence has shown that alcohol alters the activity of the innate immune system and that changes in innate immune system activity can influence alcohol-related behaviors. Here, we show that the Toll innate immune signaling pathway modulates the level of alcohol resistance in Drosophila. In humans, a low level of response to alcohol is correlated with increased risk of developing an alcohol use disorder. The Toll signaling pathway was originally discovered in, and has been extensively studied in Drosophila. The Toll pathway is a major regulator of innate immunity in Drosophila, and mammalian Toll-like receptor signaling has been implicated in alcohol responses. Here, we use Drosophila-specific genetic tools to test eight genes in the Toll signaling pathway for effects on the level of response to ethanol. We show that increasing the activity of the pathway increases ethanol resistance whereas decreasing the pathway activity reduces ethanol resistance. Furthermore, we show that gene products known to be outputs of innate immune signaling are rapidly induced following ethanol exposure. The interaction between the Toll signaling pathway and ethanol is rooted in the natural history of Drosophila melanogaster.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.