Evidence map›Paper›PMID 26916011›Full record

ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2016

Magnesium ring device to restore function of a transected anterior cruciate ligament in the goat stifle joint.

Kathryn F Farraro, Norihiro Sasaki, Savio L-Y Woo, Kwang E Kim, Matteo M Tei, Andrea Speziali, Patrick J McMahon

Open access · bronzeAbstract readEvaluation Study
In one paragraph

Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Biodegradable Magnesium-Based Implants in Orthopedics-A General Review and Perspectives.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020
    Review
  7. Article
  8. Permanent knee sensorimotor system changes following ACL injury and surgery.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2017
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Kathryn F FarraroDepartment of Bioengineering, Musculoskeletal Research Center, Swanson School of Engineering, University of Pittsburgh, 405 Center for Bioengineering, 300 Technology Drive, Pittsburgh, Pennsylvania 15219.
Norihiro SasakiDepartment of Bioengineering, Musculoskeletal Research Center, Swanson School of Engineering, University of Pittsburgh, 405 Center for Bioengineering, 300 Technology Drive, Pittsburgh, Pennsylvania 15219.
Savio L-Y WooDepartment of Bioengineering, Musculoskeletal Research Center, Swanson School of Engineering, University of Pittsburgh, 405 Center for Bioengineering, 300 Technology Drive, Pittsburgh, Pennsylvania 15219.
Kwang E KimDepartment of Bioengineering, Musculoskeletal Research Center, Swanson School of Engineering, University of Pittsburgh, 405 Center for Bioengineering, 300 Technology Drive, Pittsburgh, Pennsylvania 15219.
Matteo M TeiDepartment of Bioengineering, Musculoskeletal Research Center, Swanson School of Engineering, University of Pittsburgh, 405 Center for Bioengineering, 300 Technology Drive, Pittsburgh, Pennsylvania 15219.
Andrea SpezialiDepartment of Bioengineering, Musculoskeletal Research Center, Swanson School of Engineering, University of Pittsburgh, 405 Center for Bioengineering, 300 Technology Drive, Pittsburgh, Pennsylvania 15219.
Patrick J McMahonDepartment of Bioengineering, Musculoskeletal Research Center, Swanson School of Engineering, University of Pittsburgh, 405 Center for Bioengineering, 300 Technology Drive, Pittsburgh, Pennsylvania 15219.
University of Pittsburgh · US

Funding

Training in Biomechanics in Regenerative MedicineT32EB003392 · NIBIB · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WOO, SAVIO L-Y. · 2005 to 2020
$4.0M
NIBIB NIH HHS T32 EB003392
6 · The paper itself

Abstract

A bioresorbable, mono-crystalline magnesium (Mg) ring device and suture implantation technique were designed to connect the ends of a transected anterior cruciate ligament (ACL) to restabilize the knee and load the ACL to prevent disuse atrophy of its insertion sites and facilitate its healing. To test its application, cadaveric goat stifle joints were evaluated using a robotic/universal force-moment sensor testing system in three states: Intact, ACL-deficient, and after Mg ring repair, at 30°, 60°, and 90° of joint flexion. Under a 67-N anterior tibial load simulating that used in clinical examinations, the corresponding anterior tibial translation (ATT) and in-situ forces in the ACL and medial meniscus for 0 and 100 N of axial compression were obtained and compared with a control group treated with suture repair. In all cases, Mg ring repair reduced the ATT by over 50% compared to the ACL-deficient joint, and in-situ forces in the ACL and medial meniscus were restored to near normal levels, showing significant improvement over suture repair. These findings suggest that Mg ring repair could successfully stabilize the joint and load the ACL immediately after surgery, laying the framework for future in vivo studies to assess its utility for ACL healing. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:2001-2008, 2016.

Indexed as

Absorbable ImplantsMagnesiumAnimalsAnterior Cruciate Ligament InjuriesAnterior Cruciate Ligament ReconstructionGoatsSuture TechniquesMagnesiumACL repairanterior cruciate ligament (ACL)magnesium ring devicerobotic testing system

Identifiers

PMID26916011
PMCPMC9583724
OpenAlexW2295349227

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.