ReviewChemico-biological interactions2016
Physiological roles for butyrylcholinesterase: A BChE-ghrelin axis.
Review in Chemico-biological interactions, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it, 101 citations in OpenAlex.
- Assessment of biochemical recurrence of prostate cancer (Review).International journal of oncology · 2019Pooled it
- Adaptive variation in butyrylcholinesterase-influenced lipid metabolism during horse domestication.Cell reports · 2026Article
- Low plasma butyrylcholinesterase activity in dogs: prevalence, association with underlying disorders, laboratory variables, and survival.Journal of veterinary internal medicine · 2026Article
- Organic Sunscreens-Biological Activity from an Enzymatic Perspective.Molecules (Basel, Switzerland) · 2026Article
- Mechanistic insights into postoperative delirium using untargeted high-throughput proteomics in elderly patients - a case-control study.Scientific reports · 2026Observational
- Low Cholinesterase Is a Potential Poor Prognostic Factor in Colorectal Cancer Presenting With Tumor Markers Negative.Cancer reports (Hoboken, N.J.) · 2025Article
- Altered Plasma Butyrylcholinesterase Activity in Streptozotocin-Induced Diabetic Hypertensive Rats Does Not Reflect Impaired Liver Function.Physiological research · 2025Article
- Associations of Butyrylcholinesterase Activity and Lipid-Related Indices with Obesity in Thai Children.International journal of environmental research and public health · 2025Article
- The key role of magnesium sulfate in the management of organophosphorus pesticide poisoning: a scoping literature review.Clinical and experimental emergency medicine · 2025Article
- Discovery of novel butyrylcholinesterase inhibitors for treating Alzheimer's disease.Acta pharmaceutica Sinica. B · 2025Article
- Butyrylcholinesterase (BChE) downregulation in taxane resistance: implications for prostate cancer.Turkish journal of biology = Turk biyoloji dergisi · 2025Article
- Association of Butyryl Cholinesterase and Recurrent Ischemic Stroke: A Cross-Sectional Study.International journal of general medicine · 2025Article
- New views on physiological functions and regulation of butyrylcholinesterase and potential therapeutic interventions.Frontiers in molecular biosciences · 2025Review
- The Aggravating Role of Failing Neuropeptide Networks in the Development of Sporadic Alzheimer's Disease.International journal of molecular sciences · 2024Review
- Functional foods in Mediterranean diet: exploring the functional features of vegetable case-studies obtained also by biotechnological approaches.Aging clinical and experimental research · 2024Review
- Emerging significance of butyrylcholinesterase.World journal of experimental medicine · 2024Review
- Serum butyrylcholinesterase as a marker of COVID-19 mortality: Results of the monocentric prospective observational study.Chemico-biological interactions · 2023Observational
- Albumin Is a Component of the Esterase Status of Human Blood Plasma.International journal of molecular sciences · 2023Article
- Exploring the Multitarget Activity of Wedelolactone against Alzheimer's Disease: Insights fromACS omega · 2023Article
- Butyrylcholinesterase distribution in the mouse gastrointestinal tract: An immunohistochemical study.Journal of anatomy · 2023Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Butyrylcholinesterase (BChE) has long been regarded as an "orphan enzyme" with no specific physiological role other than to metabolize exogenous bioactive esters in the diet or in medicines. Human beings with genetic mutations that eliminate all BChE activity appear completely normal, and BChE-knockout mice have been described as "lacking a phenotype" except for faster weight gain on high-fat diets. However, our recent studies with viral gene transfer of BChE in mice reveal that BChE hydrolyzes the so-called "hunger hormone," ghrelin, at a rate which strongly affects the circulating levels of this peptide hormone. This action has important consequences for weight gain and fat metabolism. Surprisingly, it also impacts emotional behaviors such as aggression. Overexpression of BChE leads to low ghrelin levels in the blood stream and reduces aggression and social stress in mice. Under certain circumstances these combined effects contribute to increased life-span in group-housed animals. These findings may generalize to humans, as recent clinical studies by multiple investigators indicate that, among patients with severe cardiovascular disease, longevity correlates with increasing levels of plasma BChE activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.