ArticleScientific reports2016
Label-free imaging to study phenotypic behavioural traits of cells in complex co-cultures.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Ptychographic analysis of human bone marrow-derived mesenchymal stem cell morphology: The impact of cell senescence.Journal of microscopy · 2025Article
- Label-free morpho-molecular phenotyping of living cancer cells by combined Raman spectroscopy and phase tomography.Communications biology · 2024Article
- Initial refinement of data from video-based single-cell tracking.Cancer innovation · 2023Article
- The CellPhe toolkit for cell phenotyping using time-lapse imaging and pattern recognition.Nature communications · 2023Article
- Naxitamab Activity in Neuroblastoma Cells Is Enhanced by Nanofenretinide and Nanospermidine.Pharmaceutics · 2023Article
- Nanospermidine in Combination with Nanofenretinide Induces Cell Death in Neuroblastoma Cell Lines.Pharmaceutics · 2022Article
- Effects of Regioisomerism on the Antiproliferative Activity of Hydroxystearic Acids on Human Cancer Cell Lines.Molecules (Basel, Switzerland) · 2022Article
- JNK signalling regulates antioxidant responses in neurons.Redox biology · 2020Article
- Neuroprotective activity of ursodeoxycholic acid in CHMP2BNeurobiology of disease · 2020Article
- Retrovirus reactivation in CHMP2BIntron5 models of frontotemporal dementia.Human molecular genetics · 2020Article
- Metastatic breast cancer cells induce altered microglial morphology and electrical excitability in vivo.Journal of neuroinflammation · 2020Article
- Ptychographic imaging of NaD1 induced yeast cell death.Biomedical optics express · 2019Article
- Classification of M1/M2-polarized human macrophages by label-free hyperspectral reflectance confocal microscopy and multivariate analysis.Scientific reports · 2017Article
- Quadriwave lateral shearing interferometric microscopy with wideband sensitivity enhancement for quantitative phase imaging in real time.Scientific reports · 2017Article
- Automated tracking and quantification of angiogenic vessel formation in 3D microfluidic devices.PloS one · 2017Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Time-lapse imaging is a fundamental tool for studying cellular behaviours, however studies of primary cells in complex co-culture environments often requires fluorescent labelling and significant light exposure that can perturb their natural function over time. Here, we describe ptychographic phase imaging that permits prolonged label-free time-lapse imaging of microglia in the presence of neurons and astrocytes, which better resembles in vivo microenvironments. We demonstrate the use of ptychography as an assay to study the phenotypic behaviour of microglial cells in primary neuronal co-cultures through the addition of cyclosporine A, a potent immune-modulator.
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