Evidence map›Paper›PMID 26915638›Full record

ArticleDiagnostic microbiology and infectious disease2016

False-positive rifampin resistant results with Xpert MTB/RIF version 4 assay in clinical samples with a low bacterial load.

Oksana Ocheretina, Erin Byrt, Marie-Marcelle Mabou, Gertrude Royal-Mardi, Yves-Mary Merveille, Vanessa Rouzier, Daniel W Fitzgerald, Jean W Pape

Abstract read
In one paragraph

Article in Diagnostic microbiology and infectious disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Paucibacillary Tuberculosis Drives the Low Positive Predictive Value of Xpert MTB/RIF Ultra for Rifampicin Resistance Detection in Low-Prevalence Settings.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
    Article
  6. Article
  7. Targeted next-generation sequencing ofEmerging microbes & infections · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Distribution and frequency of common mutations inJournal of clinical tuberculosis and other mycobacterial diseases · 2022
    Article
  13. Article
  14. Article
  15. Review
  16. A Difficult Case of Pyrexia of Unknown Origin.Indian journal of pediatrics · 2021
    Article
  17. Need for caution when interpreting XpertThe international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2021
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Oksana OcheretinaCenter for Global Health, Division of Infectious Diseases, Department of Medicine, Weill Cornell Medical College, New York, New York; Les Centres GHESKIO, Port-au-Prince, Haiti. Electronic address: oko2001@med.cornell.edu.
Erin ByrtCenter for Global Health, Division of Infectious Diseases, Department of Medicine, Weill Cornell Medical College, New York, New York.
Marie-Marcelle MabouLes Centres GHESKIO, Port-au-Prince, Haiti.
Gertrude Royal-MardiLes Centres GHESKIO, Port-au-Prince, Haiti.
Yves-Mary MerveilleLes Centres GHESKIO, Port-au-Prince, Haiti.
Vanessa RouzierLes Centres GHESKIO, Port-au-Prince, Haiti.
Daniel W FitzgeraldCenter for Global Health, Division of Infectious Diseases, Department of Medicine, Weill Cornell Medical College, New York, New York.
Jean W PapeCenter for Global Health, Division of Infectious Diseases, Department of Medicine, Weill Cornell Medical College, New York, New York; Les Centres GHESKIO, Port-au-Prince, Haiti.

Funding

Viable but Nonculturable MtbU19AI111143 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI DARTOIS, VERONIQUE, GLICKMAN, MICHAEL S · 2014 to 2020
$48.6M
GHESKIO HIV Clinical Trial UnitUM1AI069421 · NIAID · GHESKIO CENTER · PI JEAN WILLIAM PAPE · 2012 to 2026
$23.6M
Training in pharmacokinetic and pharmacodynamics research in HIV and tuberculosisD43TW010062 · FIC · WEILL MEDICAL COLL OF CORNELL UNIV · PI FITZGERALD, DANIEL W · 2015 to 2019
$1.8M
Global Health Research Training in HIV and TuberculosisK24AI098627 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI FITZGERALD, DANIEL W · 2012 to 2022
$1.8M
FIC NIH HHS 1D43TW010062FIC NIH HHS D43 TW010062NIAID NIH HHS 1U19AI111143NIAID NIH HHS 5K24AI098627NIAID NIH HHS K24 AI098627NIAID NIH HHS U19 AI111143NIAID NIH HHS UM1 AI069421PEPFAR 541PEPFAR 545
6 · The paper itself

Abstract

We report investigation of 22 TB cases with positive Xpert MTB/RIF result for resistance to Rifampin and "Very Low" MTB detection level. Twelve cases were false positive without rpoB mutations, 2 were false-positives with a silent mutation in rpoB codon T508, and only 10 were true positives.

Indexed as

Bacterial LoadMicrobial Sensitivity TestsReal-Time Polymerase Chain ReactionHumansMutationMycobacterium tuberculosisReproducibility of ResultsRifampinSputumTuberculosis, Multidrug-ResistantTuberculosis, PulmonaryRifampinDeveloping and high-burden countriesMDR-TBMolecular diagnosticsTuberculosisXpert MTB/RIF

Identifiers

PMID26915638
PMCPMC4841693

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.