Evidence map›Paper›PMID 26915609›Full record

ArticleAnnals of laboratory medicine2016

Potential Risk Factors Associated With Vascular Diseases in Patients Receiving Treatment for Hypertension.

Hyunjung Kim, Joonhong Park, Hyojin Chae, Gun Dong Lee, Sang Yoon Lee, Jong Min Lee, Yong Seog Oh, Myungshin Kim, Yonggoo Kim

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of laboratory medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Hyunjung KimDepartment of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Joonhong ParkDepartment of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Hyojin ChaeDepartment of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Gun Dong LeeDepartment of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Sang Yoon LeeDepartment of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Jong Min LeeDivision of Cardiology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Yong Seog OhDivision of Cardiology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Myungshin KimDepartment of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Yonggoo KimDepartment of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Catholic University of Korea · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCurrently, the hypertension (HTN) patients undergo appropriate medical treatment, and traditional risk factors are highly controlled. Therefore, potential risk factors of atherosclerotic vascular diseases (AVD) and venous thromboembolisms (VTE) in HTN should be reconsidered. We investigated thrombophilic genetic mutations and existing biomarkers for AVD or VTE in HTN patients receiving treatment.

methodsA total of 183 patients were enrolled: AVD with HTN (group A, n=45), VTE with HTN (group B, n=62), and HTN patients without any vascular diseases (group C, n=76). The lipid profile, homocysteine (Hcy) levels, D-dimers, fibrinogen, antithrombin, lupus anticoagulant, and anti-cardiolipin antibody (aCL) were evaluated. Prothrombin G20210A, Factor V G1691A, and methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C were analyzed.

resultsAll patients revealed wild type prothrombin G20210A and Factor V G1691A polymorphisms. The frequency of MTHFR polymorphisms was 677CT (n=84, 45.9%); 677TT (n=46, 25.1%); 1298AC (n=46, 25.1%); and 1298CC (n=2, 1.1%). The MTHFR 677TT genotype tended to increase the odds ratio (OR) to AVD events in HTN patients (OR 2.648, confidence interval 0.982-7.143, P=0.05). The group A demonstrated significantly higher Hcy levels (P=0.009), fibrinogen (P=0.004), and platelet counts (P=0.04) than group C. Group B had significantly higher levels of D-dimers (P=0.0001), platelet count (P=0.0002), and aCL (P=0.02) frequency than group C.

conclusionsThe MTHFR 677TT genotype and Hcy level could be potential risk factors associated with development of AVD in HTN patients receiving treatment. D-dimer and aCL might be useful to estimate the occurrence of VTE in them.

Indexed as

AdultAgedAntihypertensive AgentsDNAFactor VFemaleFibrin Fibrinogen Degradation ProductsGenotypeHomocysteineHumansHypertensionLipidsMaleMethylenetetrahydrofolate Reductase (NADPH2)Middle AgedOdds RatioAntihypertensive AgentsDNAFactor VFibrin Fibrinogen Degradation Productsfibrin fragment DHomocysteineLipidsMethylenetetrahydrofolate Reductase (NADPH2)MTHFR protein, humanProthrombinAtherosclerotic vascular diseaseHomocysteineHypertensionMTHFR C677TVenous thrombosis

Identifiers

PMID26915609
PMCPMC4773261
OpenAlexW2273978255

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.