ArticleJournal of stroke2016
Differentiating Carotid Terminus Occlusions into Two Distinct Populations Based on Willisian Collateral Status.
Article in Journal of stroke, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Circle of Willis Configuration and Thrombus Localization Impact on Ischemic Stroke Patient Outcomes: A Systematic Review.Medicina (Kaunas, Lithuania) · 2023Pooled it
- Large Core Trial.AJNR. American journal of neuroradiology · 2025Review
- Association of Narrow Anterior Communicating Artery or Contralateral A1 Segment with Poor Outcomes After Mechanical Thrombectomy.Medicina (Kaunas, Lithuania) · 2024Article
- Higher number of stent-retriever thrombectomy passes significantly increases risk of mass effect, poor functional outcome, and mortality.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2023Article
- Collateral Circulation in Ischemic Stroke: An Updated Review.Journal of stroke · 2023Review
- Ischemic Lesion Growth in Patients with a Persistent Target Mismatch After Large Vessel Occlusion.Clinical neuroradiology · 2023Article
- Neuroimaging of Acute Ischemic Stroke: Multimodal Imaging Approach for Acute Endovascular Therapy.Journal of stroke · 2023Review
- Leptomeningeal anastomoses: Mechanisms of pial collateral remodeling in ischemic stroke.WIREs mechanisms of disease · 2022Review
- Functional Aplasia of the Contralateral A1 Segment Influences Clinical Outcome in Patients with Occlusion of the Distal Internal Carotid Artery.Journal of clinical medicine · 2022Article
- Factors Contributing to an Efficacious Endovascular Treatment for Acute Ischemic Stroke in Asian Population.Neurointervention · 2021Review
- Mechanical Thrombectomy for Acute Intracranial Carotid Occlusion with Patent Intracranial Arteries : The Italian Registry of Endovascular Treatment in Acute Stroke.Clinical neuroradiology · 2021Article
- Predictors and prognoses of Willisian collateral failure during mechanical thrombectomy.Scientific reports · 2020Article
- Optic nerve sheath diameter change in prediction of malignant cerebral edema in ischemic stroke: an observational study.BMC neurology · 2020Observational
- Collateral grade of the Willis' circle predicts outcomes of acute intracranial internal carotid artery occlusion before thrombectomy.Brain and behavior · 2019Article
- Genetic and Environmental Contributions to Variation in the Posterior Communicating Collaterals of the Circle of Willis.Translational stroke research · 2019Article
- Efficacy and Safety of Endovascular Treatment in Patients with Internal Carotid Artery Occlusion and Collateral Middle Cerebral Artery Flow.Journal of Korean Neurosurgical Society · 2019Article
- Prognosis of Acute Intracranial Atherosclerosis-Related Occlusion after Endovascular Treatment.Journal of stroke · 2018Article
- Endovascular Thrombectomy in Acute Ischemic Stroke: Outcome in Referred Versus Directly Admitted Patients.Clinical neuroradiology · 2018Article
- Cerebral infarct volume measurements to improve patient selection for endovascular treatment.Medicine · 2016Observational
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThe outcomes of acute internal carotid artery (ICA) terminus occlusions are poor. We classified ICA terminus occlusions into 2 groups according to the occlusion pattern of the circle of Willis and hypothesized that clinical outcomes would significantly differ between them.
methodsConsecutive patients with acute ICA terminus occlusions evaluated by baseline computed tomographic angiography were enrolled. We investigated the occlusion patterns in the circle of Willis, retrospectively classified patients into simple ICA terminus occlusion (STO; with good Willisian collaterals from neighboring cerebral circulation) and complex ICA terminus occlusion (CTO; with one or more of A2 anterior cerebral artery, fetal posterior cerebral artery occlusion, or hypoplastic/absent contralateral A1; or with poor collaterals from anterior communicating artery) groups, and compared their baseline characteristics and outcomes.
resultsThe STO group (n=58) showed smaller infarct volumes at 72 hours than the CTO group (n=34) (median, 81 mL [interquartile range, 38-192] vs. 414 mL [193-540], P<0.001) and more favorable outcomes (3-month modified Rankin Scale 0-3, 44.8% vs. 8.8%, P<0.001; 3-month mortality, 24.1% vs. 67.6%, P<0.001). In multivariable analyses, STO remained an independent predictor for favorable outcomes (odds ratio 6.1, P=0.010).
conclusionsFavorable outcomes in STO group suggested that the outcomes of acute ICA terminus occlusions depend on Willisian collateral status. Documenting the subtypes on computed tomographic angiography would help predict patient outcome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.