ArticleScientific reports2016
Vortex ring behavior provides the epigenetic blueprint for the human heart.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Integrated Strain-Flow Analysis for Early Assessment of Right Ventricular Dysfunction in Pulmonary Arterial Hypertension.Annals of biomedical engineering · 2026Article
- Intracardiac fluid dynamic analysis: available techniques and novel clinical applications.BMC cardiovascular disorders · 2024Review
- Early-Onset Fetal Growth Restriction Increases Left Ventricular Sphericity in Adolescents Born Very Preterm.Pediatric cardiology · 2024Article
- Enhancement of intra-cardiac flow-field data using adaptive Kernel filtering.Scientific reports · 2023Article
- Novel insights into diminished cardiac reserve in non-obstructive hypertrophic cardiomyopathy from four-dimensional flow cardiac magnetic resonance component analysis.European heart journal. Cardiovascular Imaging · 2023Article
- Recasting Current Knowledge of Human Fetal Circulation: The Importance of Computational Models.Journal of cardiovascular development and disease · 2023Review
- Comparison of Four-Dimensional Magnetic Resonance Imaging Analysis of Left Ventricular Fluid Dynamics and Energetics in Ischemic and Restrictive Cardiomyopathies.Journal of magnetic resonance imaging : JMRI · 2022Observational
- Four-dimensional flow cardiac magnetic resonance assessment of left ventricular diastolic function.Frontiers in cardiovascular medicine · 2022Review
- MVnet: automated time-resolved tracking of the mitral valve plane in CMR long-axis cine images with residual neural networks: a multi-center, multi-vendor study.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2021Article
- Septaly Oriented Mild Aortic Regurgitant Jets Negatively Influence Left Ventricular Blood Flow-Insights From 4D Flow MRI Animal Study.Frontiers in cardiovascular medicine · 2021Article
- Automated mitral valve vortex ring extraction from 4D-flow MRI.Magnetic resonance in medicine · 2020Article
- Cardiac Magnetic Resonance Imaging in Pulmonary Arterial Hypertension: Ready for Clinical Practice and Guidelines?Current heart failure reports · 2020Review
- Valvular imaging in the era of feature-tracking: A slice-following cardiac MR sequence to measure mitral flow.Journal of magnetic resonance imaging : JMRI · 2020Article
- Changes in left ventricular blood flow during diastole due to differences in chamber size in healthy dogs.Scientific reports · 2020Article
- Left Ventricular Response to Cardiac Resynchronization Therapy: Insights From Hemodynamic Forces Computed by Speckle Tracking.Frontiers in cardiovascular medicine · 2019Article
- Investigation of Atrial Vortices Using a Novel Right Heart Model and Possible Implications for Atrial Thrombus Formation.Scientific reports · 2017Article
- High-speed, high-frequency ultrasound, in utero vector-flow imaging of mouse embryos.Scientific reports · 2017Article
- Left ventricular hemodynamic forces as a marker of mechanical dyssynchrony in heart failure patients with left bundle branch block.Scientific reports · 2017Article
- Decreased Diastolic Ventricular Kinetic Energy in Young Patients with Fontan Circulation Demonstrated by Four-Dimensional Cardiac Magnetic Resonance Imaging.Pediatric cardiology · 2017Article
- Closure of atrial septal defect normalizes left and right ventricular hemodynamic forces in children and adolescents.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic ResonanceArticle
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The laws of fluid dynamics govern vortex ring formation and precede cardiac development by billions of years, suggesting that diastolic vortex ring formation is instrumental in defining the shape of the heart. Using novel and validated magnetic resonance imaging measurements, we show that the healthy left ventricle moves in tandem with the expanding vortex ring, indicating that cardiac form and function is epigenetically optimized to accommodate vortex ring formation for volume pumping. Healthy hearts demonstrate a strong coupling between vortex and cardiac volumes (R(2) = 0.83), but this optimized phenotype is lost in heart failure, suggesting restoration of normal vortex ring dynamics as a new, and possibly important consideration for individualized heart failure treatment. Vortex ring volume was unrelated to early rapid filling (E-wave) velocity in patients and controls. Characteristics of vortex-wall interaction provide unique physiologic and mechanistic information about cardiac diastolic function that may be applied to guide the design and implantation of prosthetic valves, and have potential clinical utility as therapeutic targets for tailored medicine or measures of cardiac health.
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