ArticlePLoS computational biology2016
Cell Assembly Dynamics of Sparsely-Connected Inhibitory Networks: A Simple Model for the Collective Activity of Striatal Projection Neurons.
Article in PLoS computational biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Pathological cell assembly dynamics in a striatal MSN network model.Frontiers in computational neuroscience · 2024Article
- Patterns of synchronization in 2D networks of inhibitory neurons.Frontiers in computational neuroscience · 2022Article
- Ramping activity in the striatum.Frontiers in computational neuroscience · 2022Article
- Striatal network modeling in Huntington's Disease.PLoS computational biology · 2020Article
- Bifurcation analysis of the dynamics of interacting subnetworks of a spiking network.Scientific reports · 2019Article
- Exploring the role of striatal D1 and D2 medium spiny neurons in action selection using a virtual robotic framework.The European journal of neuroscience · 2019Article
- A Finite State Machine Approach to Algorithmic Lateral Inhibition for Real-Time Motion DetectionSensors (Basel, Switzerland) · 2018Article
- Article
- A Pause-then-Cancel model of stopping: evidence from basal ganglia neurophysiology.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Striatal Network Models of Huntington's Disease Dysfunction Phenotypes.Frontiers in computational neuroscience · 2017Article
- Forgetting in Reinforcement Learning Links Sustained Dopamine Signals to Motivation.PLoS computational biology · 2016Article
- Article
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Authors and funding
3 authors.
Funding
Abstract
Striatal projection neurons form a sparsely-connected inhibitory network, and this arrangement may be essential for the appropriate temporal organization of behavior. Here we show that a simplified, sparse inhibitory network of Leaky-Integrate-and-Fire neurons can reproduce some key features of striatal population activity, as observed in brain slices. In particular we develop a new metric to determine the conditions under which sparse inhibitory networks form anti-correlated cell assemblies with time-varying activity of individual cells. We find that under these conditions the network displays an input-specific sequence of cell assembly switching, that effectively discriminates similar inputs. Our results support the proposal that GABAergic connections between striatal projection neurons allow stimulus-selective, temporally-extended sequential activation of cell assemblies. Furthermore, we help to show how altered intrastriatal GABAergic signaling may produce aberrant network-level information processing in disorders such as Parkinson's and Huntington's diseases.
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Registered trials
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