ArticleJournal of experimental orthopaedics2015
Intratendinous injections of platelet-rich plasma: feasibility and effect on tendon morphology and mechanics.
Article in Journal of experimental orthopaedics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
8 citing papers in PubMed.
- Effect of platelet-rich plasma on the degenerative rotator cuff tendinopathy according to the compositions.Journal of orthopaedic surgery and research · 2019Trial
- Article
- Intra-flexor retinaculum steroid injection in elderly patients with carpal tunnel syndrome: A randomized clinical trial.Interventional pain medicine · 2022Article
- Platelet-Rich Plasma Diffusion in Achilles Tendon: Relationship with Therapeutic Outcomes.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2019Observational
- The spread of Injectate after ultrasound-guided lateral elbow injection - a cadaveric study.Journal of experimental orthopaedics · 2018Article
- Platelet-rich plasma has beneficial effects in mice with osteonecrosis of the femoral head by promoting angiogenesis.Experimental and therapeutic medicine · 2018Article
- Optimisation of platelet concentrates therapy: Composition, localisation, and duration of action.Asia-Pacific journal of sports medicine, arthroscopy, rehabilitation and technology · 2017Review
- Anaesthetics, steroids and platelet-rich plasma (PRP) in ultrasound-guided musculoskeletal procedures.The British journal of radiology · 2016Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntratendinous injections may have important effects on the properties of collagen microarchitecture, morphology, and subsequent mechanical properties of the injected tendon. The purpose of this study was to examine the effects of intratendinous PRP injections; the injectant retention within tendons, the distribution of intratendinous injectant, and whether intratendinous injection or needle fenestration alters tendon morphology or mechanics.
methods
designControlled Laboratory Study.
interventionsIn the first part of the study, 18 lamb extensor tendons were selected to receive methylene blue-containing PRP injection (PRP/MB), methylene blue only injection (MB), or needle fenestration. The volume of retained injectant was measured and injectant distribution and tendon morphology were examined microscopically. In the second portion of the study, 18 porcine flexor tendons were divided into control, needle fenestration, or saline injection groups. Young's Modulus was then determined for each tendon under 0-4% strain.
main outcome measures1) Injectant volume retained; 2) Injectant distribution; 3) Post-injection/fenestration alterations in morphology, biomechanics.
resultsIntratendinous injectant is retained within the tendon. The difference between PRP and PRP/MB groups was not significant (p = 0.78). Intratendinous spread of the injectant solution within the tendon occurs primarily in the proximodistal direction, with very little cross-sectional penetration. Intratendinous injections resulted in microscopic morphology disruption (e.g., separation and disorganization of both the collagen bundles and cellular distribution). There were significant differences in Young's Modulus between control (Ectrl = 2415.48) and injected tendons (Einj = 1753.45) at 4% strain (p = 0.01). There were no differences in Young's Modulus between fenestrated and control tendons.
conclusionsIntratendinous PRP injections are retained within the tendon, and primarily distributes longitudinally with minimal cross-sectional spread. Intratendinous injections may alter tendon morphology and mechanics.
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Registered trials
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