Evidence map›Paper›PMID 26914834›Full record

ArticleJournal of clinical nursing2016

Refusal to participate in heart failure studies: do age and gender matter?

Jordan M Harrison, Miyeon Jung, Terry A Lennie, Debra K Moser, Dean G Smith, Sandra B Dunbar, David L Ronis, Todd M Koelling, Bruno Giordani, Penny L Riley and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical nursing, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 25 citations in OpenAlex.

  1. Trial
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  11. 'Sick and tired': Patients reported reasons for not participating in clinical psychiatric research.Health expectations : an international journal of public participation in health care and health policy · 2021
    Article
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  15. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Jordan M HarrisonSchool of Nursing, University of Michigan, Ann Arbor, MI, USA.
Miyeon JungSchool of Nursing, Indiana University, Indianapolis, IN, USA.
Terry A LennieCollege of Nursing, University of Kentucky, Lexington, KY, USA.
Debra K MoserCollege of Nursing, University of Kentucky, Lexington, KY, USA.
Dean G SmithLouisiana State University Health Sciences Center School of Public Health, New Orleans, LA, USA.
Sandra B DunbarNell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA, USA.
David L RonisSchool of Nursing, University of Michigan, Ann Arbor, MI, USA.
Todd M KoellingDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Bruno GiordaniDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
Penny L RileySchool of Nursing, University of Michigan, Ann Arbor, MI, USA.
Susan J PresslerCenter for Enhancing Quality of Life in Chronic Illness, School of Nursing, Indiana University, Indianapolis, IN, USA.
University of Michigan–Ann Arbor · USIndiana University IndianapolisUniversity of Kentucky · USEmory University · USLouisiana State University Health Sciences Center New Orleans · US

Funding

Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
Michigan Institute for Clinical and Health Research (MCHR)UL1TR000433 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER · 2012 to 2016
$49.9M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025008 · NCRR · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2007 to 2011
$29.0M
ZOSUQUIDAR TRIHYDROCHLORIDE DURING CONVENTIONAL INDUCTION AND POST-REMISSIONM01RR000750 · NCRR · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI RODRIGUEZ, HENRY · 1985 to 2008
$25.5M
X LINKED NYSTAGMUS SYNDROME WITH FEATURES OF ALBINISMM01RR000039 · NCRR · EMORY UNIVERSITY · PI VACCARINO, VIOLA · 1985 to 2007
$21.3M
XENOBIOTIC TRANSFER INTO MILK NITROFURANTOINM01RR002602 · NCRR · UNIVERSITY OF KENTUCKY · PI MOSER, DEBRA KAY · 1985 to 2007
$12.1M
Translation and Dissemination CoreP30NR009000 · NINR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALGASE, DONNA L. · 2005 to 2009
$2.1M
BMI, Nutrition, Inflammation and Heart Failure OutcomesR01NR009280 · NINR · UNIVERSITY OF KENTUCKY · PI LENNIE, TERRY A · 2005 to 2007
$1.5M
Self-Management Pilot/Feasibility and Biobehavioral Outcomes CoreP20NR010679 · NINR · UNIVERSITY OF KENTUCKY · PI MOSER, DEBRA KAY · 2007 to 2011
$1.2M
The Role of Cognitive Deficits in Chronic Heart FailureR01NR008147 · NINR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PRESSLER, SUSAN J · 2004 to 2007
$1.1M
NCATS NIH HHS 2UL1TR000433NCATS NIH HHS UL1 TR000433NCATS NIH HHS UL1 TR002378NCRR NIH HHS M01 RR000039NCRR NIH HHS M01 RR000750NCRR NIH HHS M01 RR002602NCRR NIH HHS M01RR0039NCRR NIH HHS M01RR02602NCRR NIH HHS UL1 RR025008NINR NIH HHS 1P20NR010679NINR NIH HHS P20 NR010679NINR NIH HHS P30 NR009000NINR NIH HHS R01 NR008147NINR NIH HHS R01 NR009280
6 · The paper itself

Abstract

AIMS AND

objectivesThe objective of this retrospective study was to evaluate reasons heart failure patients decline study participation, to inform interventions to improve enrollment.

backgroundFailure to enrol older heart failure patients (age > 65) and women in studies may lead to sampling bias, threatening study validity.

designThis study was a retrospective analysis of refusal data from four heart failure studies that enrolled 788 patients in four states.

methodsChi-Square and a pooled t-test were computed to analyse refusal data (n = 300) obtained from heart failure patients who were invited to participate in one of the four studies but declined.

resultsRefusal reasons from 300 patients (66% men, mean age 65·33) included: not interested (n = 163), too busy (n = 64), travel burden (n = 50), too sick (n = 38), family problems (n = 14), too much commitment (n = 13) and privacy concerns (n = 4). Chi-Square analyses showed no differences in frequency of reasons (p > 0·05) between men and women. Patients who refused were older, on average, than study participants.

conclusionsSome reasons were patient-dependent; others were study-dependent. With 'not interested' as the most common reason, cited by over 50% of patients who declined, recruitment measures should be targeted at stimulating patients' interest. Additional efforts may be needed to recruit older participants. However, reasons for refusal were consistent regardless of gender. RELEVANCE TO CLINICAL PRACTICE: Heart failure researchers should proactively approach a greater proportion of women and patients over age 65. With no gender differences in type of reasons for refusal, similar recruitment strategies can be used for men and women. However, enrolment of a representative proportion of women in heart failure studies has proven elusive and may require significant effort from researchers. Employing strategies to stimulate interest in studies is essential for recruiting heart failure patients, who overwhelmingly cited lack of interest as the top reason for refusal.

Indexed as

Refusal to ParticipateAgedAge FactorsBiomedical ResearchFemaleHeart FailureHumansMaleMiddle AgedPatient SelectionRetrospective StudiesSex Factorscardiovascularheart diseaseolderresearchwomen

Identifiers

PMID26914834
PMCPMC5897906
OpenAlexW2281776344

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.