Evidence map›Paper›PMID 26914592›Full record

Trial reportAmerican journal of respiratory and critical care medicine2016

Effect of Positive Airway Pressure on Cardiovascular Outcomes in Coronary Artery Disease Patients with Nonsleepy Obstructive Sleep Apnea. The RICCADSA Randomized Controlled Trial.

Yüksel Peker, Helena Glantz, Christine Eulenburg, Karl Wegscheider, Johan Herlitz, Erik Thunström

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in American journal of respiratory and critical care medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00519597 (Randomized Intervention With CPAP in Coronary Artery Disease and Sleep Apnea - RICCADSA Trial), which is not on this map. Cited by 383 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
383citing papers in PubMed, 13 pooled it
39.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00519597 phase4completednot on this map

Randomized Intervention With CPAP in Coronary Artery Disease and Sleep Apnea - RICCADSA Trial

TypeinterventionalSponsorSkaraborg HospitalRan2005 to 2013Enrolled511ConditionsCoronary Artery Disease, Obstructive Sleep ApneaArmsResMed S8 (Auto-CPAP)
3 · Its place in the literature

Who cites it

383 citing papers in PubMed, 13 syntheses or guidelines pooled it, 707 citations in OpenAlex.

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  6. Long-term effects on clinical event, mental health, and related outcomes of CPAP for obstructive sleep apnea: a systematic review.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024
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  8. Large variability in definitions of sleep apnea indices used in clinical studies.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024
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323 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Yüksel Peker1 Department of Molecular and Clinical Medicine/Cardiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID 0000-0001-9067-6538
Helena Glantz1 Department of Molecular and Clinical Medicine/Cardiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Christine Eulenburg4 Department of Medical Biometry and Epidemiology, University Medical Center, Hamburg-Eppendorf, Germany.ORCID 0000-0001-9365-5548
Karl Wegscheider4 Department of Medical Biometry and Epidemiology, University Medical Center, Hamburg-Eppendorf, Germany.ORCID 0000-0003-2974-3142
Johan Herlitz5 Center of Prehospital Care of Western Sweden, University College of Borås, Borås, Sweden.ORCID 0000-0003-4139-6235
Erik Thunström1 Department of Molecular and Clinical Medicine/Cardiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID 0000-0002-9134-2107
Sahlgrenska University Hospital · SEUniversität Hamburg · DEMarmara University · TRSkaraborg Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleObstructive sleep apnea (OSA) is common in patients with coronary artery disease (CAD), many of whom do not report daytime sleepiness. First-line treatment for symptomatic OSA is continuous positive airway pressure (CPAP), but its value in patients without daytime sleepiness is uncertain.

objectivesTo determine the effects of CPAP on long-term adverse cardiovascular outcome risk in patients with CAD with nonsleepy OSA.

methodsThis single-center, prospective, randomized, controlled, open-label, blinded evaluation trial was conducted between December 2005 and November 2010. Consecutive patients with newly revascularized CAD and OSA (apnea-hypopnea index ≥15/h) without daytime sleepiness (Epworth Sleepiness Scale score <10) were randomized to auto-titrating CPAP (n = 122) or no positive airway pressure (n = 122). MEASUREMENTS AND MAIN

resultsThe primary endpoint was the first event of repeat revascularization, myocardial infarction, stroke, or cardiovascular mortality. Median follow-up was 57 months. The incidence of the primary endpoint did not differ significantly in patients who did versus did not receive CPAP (18.1% vs. 22.1%; hazard ratio, 0.80; 95% confidence interval, 0.46-1.41; P = 0.449). Adjusted on-treatment analysis showed a significant cardiovascular risk reduction in those who used CPAP for ≥4 versus <4 hours per night or did not receive treatment (hazard ratio, 0.29; 95% confidence interval, 0.10-0.86; P = 0.026).

conclusionsRoutine prescription of CPAP to patients with CAD with nonsleepy OSA did not significantly reduce long-term adverse cardiovascular outcomes in the intention-to-treat population. There was a significant reduction after adjustment for baseline comorbidities and compliance with the treatment. Clinical trial registered with www.clinicaltrials.gov (NCT 00519597).

Indexed as

Continuous Positive Airway PressureComorbidityCoronary Artery DiseaseHumansKaplan-Meier EstimateMiddle AgedMyocardial RevascularizationOutcome Assessment, Health CarePercutaneous Coronary InterventionProportional Hazards ModelsProspective StudiesSleep Apnea, ObstructiveSwedencardiovascular outcomescoronary artery diseaseobstructive sleep apnea

Identifiers

PMID26914592
OpenAlexW2279209513

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.