ArticleDevelopmental neurobiology2016
En1 is necessary for survival of neurons in the ventral nuclei of the lateral lemniscus.
Article in Developmental neurobiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Molecular identity of the lateral lemniscus nuclei in the adult mouse brain.Frontiers in neuroanatomy · 2023Article
- Single-cell transcriptomic analysis of the tumor ecosystem of adenoid cystic carcinoma.Frontiers in oncology · 2022Article
- The Untouchable Ventral Nucleus of the Trapezoid Body: Preservation of a Nucleus in an Animal Model of Autism Spectrum Disorder.Frontiers in integrative neuroscience · 2021Article
- Transcriptional identification of genes light-interacting in the extraretinal photoreceptors of the crayfishZooKeys · 2021Article
- Glial Cell Expansion Coincides with Neural Circuit Formation in the Developing Auditory Brainstem.Developmental neurobiology · 2018Article
- Nuclear derivatives and axonal projections originating from rhombomere 4 in the mouse hindbrain.Brain structure & function · 2017Article
- Cellular and Molecular Underpinnings of Neuronal Assembly in the Central Auditory System during Mouse Development.Frontiers in neural circuits · 2017Review
- Functional Role of γ-Crystallin N in the Auditory Hindbrain.PloS one · 2016Article
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5 authors.
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Abstract
The ventral nuclei of the lateral lemniscus (VNLL) are part of the central auditory system thought to participate in temporal sound processing. While the timing and location of VNLL neurogenesis have been determined, the genetic factors that regulate VNLL neuron development are unknown. Here, we use genetic fate-mapping techniques to demonstrate that all glycinergic and glycinergic/GABAergic VNLL neurons derive from a cellular lineage that expresses the homeobox transcription factor Engrailed 1 (En1). We also show that En1 deletion does not affect migration or adoption of a neuronal cell fate but does lead to VNLL neuron death during development. Furthermore, En1 deletion blocks expression of the transcription factor FoxP1 in a subset of VNLL neurons. Together, these data identify En1 as a gene important for VNLL neuron development and survival. © 2016 Wiley Periodicals, Inc. Develop Neurobiol 76: 1266-1274, 2016.
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