Evidence map›Paper›PMID 26914450›Full record

ArticlePloS one2016

The Influence of Socioeconomic Status on Selection of Anticoagulation for Atrial Fibrillation.

Michelle Sholzberg, Tara Gomes, David N Juurlink, Zhan Yao, Muhammad M Mamdani, Andreas Laupacis

Abstract read
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Trial
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  4. Social drivers in atrial fibrillation occurrence, screening, treatment, and outcomes: systematic-narrative hybrid review.European heart journal supplements : journal of the European Society of Cardiology · 2024
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  11. Social determinants of atrial fibrillation.Nature reviews. Cardiology · 2021
    Review
  12. Article
  13. 2021 European Heart Rhythm Association Practical Guide on the Use of Non-Vitamin K Antagonist Oral Anticoagulants in Patients with Atrial Fibrillation.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Michelle SholzbergDepartment of Medicine, St. Michael's Hospital, Toronto, Ontario, Canada.
Tara GomesLi Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Ontario, Canada.
David N JuurlinkFaculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Zhan YaoInstitute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.
Muhammad M MamdaniLi Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Ontario, Canada.
Andreas LaupacisDepartment of Medicine, St. Michael's Hospital, Toronto, Ontario, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

importanceWithout third-party insurance, access to marketed drugs is limited to those who can afford to pay. We examined this phenomenon in the context of anticoagulation for patients with nonvalvular atrial fibrillation (NVAF).

objectiveTo determine whether, among older Ontarians receiving anticoagulation for NVAF, patients of higher socioeconomic status (SES) were more likely to switch from warfarin to dabigatran prior to its addition to the provincial formulary. DESIGN, SETTING AND

participantsPopulation-based retrospective cohort study of Ontarians aged 66 years and older, between 2008 and 2012. EXPOSURE: Socioeconomic status, as approximated by median neighborhood income. MAIN OUTCOMES AND MEASURE: We identified two groups of older adults with nonvalvular atrial fibrillation: those who appeared to switch from warfarin to dabigatran after its market approval but prior to its inclusion on the provincial formulary ("switchers"), and those with ongoing warfarin use during the same interval ("non-switchers").

resultsWe studied 34,797 patients, including 3183 "switchers" and 31,614 "non-switchers". We found that higher SES was associated with switching to dabigatran prior to its coverage on the provincial formulary (p<0.0001). In multivariable analysis, subjects in the highest quintile were 50% more likely to switch to dabigatran than those in the lowest income quintile (11.3% vs. 7.3%; adjusted odds ratio 1.50; 95% CI 1.32 to 1.68). Following dabigatran's addition to the formulary, the income gradient disappeared. CONCLUSIONS AND RELEVANCE: We documented socioeconomic inequality in access to dabigatran among patients receiving warfarin for NVAF. This disparity was eliminated following the drug's addition to the provincial formulary, highlighting the importance of timely reimbursement decisions.

Indexed as

Choice BehaviorSocial ClassAgedAnticoagulantsAtrial FibrillationDabigatranFemaleHumansMaleRetrospective StudiesWarfarinAnticoagulantsDabigatranWarfarin

Identifiers

PMID26914450
PMCPMC4767939

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.