Evidence map›Paper›PMID 26914269›Full record

ReviewSports medicine (Auckland, N.Z.)2016

Telomere Length Maintenance and Cardio-Metabolic Disease Prevention Through Exercise Training.

Joshua Denham, Brendan J O'Brien, Fadi J Charchar

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Sports medicine (Auckland, N.Z.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05684367 (Center-Based and Home-Based Walking Exercise Intervention to Reduce Fatigue in Older Breast Cancer Survivors), which is not on this map. Cited by 46 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05684367 narecruitingnot on this mapstarted 2023, after this paper: background citation

Center-Based and Home-Based Walking Exercise Intervention to Reduce Fatigue in Older Breast Cancer Survivors

TypeinterventionalSponsorUniversity of FloridaRan2023 to 2026Enrolled24ConditionsFatigue, Breast Cancer, Cancer, Therapy-RelatedArmsCenter-Based Walking Exercise, Home-Based Walking Exercise
3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. A Systematic Review and Meta-analysis Highlights a Link Between Aerobic Fitness and Telomere Maintenance.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Trial
  10. Article
  11. Review
  12. Article
  13. Exercise attenuates the hallmarks of aging: Novel perspectives.Journal of sport and health science · 2025
    Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Joshua DenhamSchool of Science and Technology, University of New England, Armidale, NSW, Australia. jdenham2@une.edu.au.
Brendan J O'BrienFaculty of Health, Federation University Australia, University Drive, Mt Helen, VIC, Australia.
Fadi J CharcharFaculty of Science and Technology, Federation University Australia, University Drive, Mt Helen, VIC, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Telomeres are tandem repeat DNA sequences located at distal ends of chromosomes that protect against genomic DNA degradation and chromosomal instability. Excessive telomere shortening leads to cellular senescence and for this reason telomere length is a marker of biological age. Abnormally short telomeres may culminate in the manifestation of a number of cardio-metabolic diseases. Age-related cardio-metabolic diseases attributable to an inactive lifestyle, such as obesity, type 2 diabetes mellitus and cardiovascular disease, are associated with short leukocyte telomeres. Exercise training prevents and manages the symptoms of many cardio-metabolic diseases whilst concurrently maintaining telomere length. The positive relationship between exercise training, physical fitness and telomere length raises the possibility of a mediating role of telomeres in chronic disease prevention via exercise. Further elucidation of the underpinning molecular mechanisms of how exercise maintains telomere length should provide crucial information on how physical activity can be best structured to combat the chronic disease epidemic and improve the human health span. Here, we synthesise and discuss the current evidence on the impact of physical activity and cardiorespiratory fitness on telomere dynamics. We provide the molecular mechanisms with a known role in exercise-induced telomere length maintenance and highlight unexplored, alternative pathways ripe for future investigations.

Indexed as

Cardiorespiratory FitnessAgingCardiovascular DiseasesExerciseHumansMetabolic DiseasesPhysical EnduranceShelterin ComplexTelomeraseTelomere-Binding ProteinsTelomere HomeostasisShelterin ComplexTelomeraseTelomere-Binding Proteins

Identifiers

PMID26914269

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.