ArticlePloS one2016
Toxic Diatom Aldehydes Affect Defence Gene Networks in Sea Urchins.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Identification of hub genes involved in early-onset schizophrenia: from genetic susceptibility to predicted regulated gene expression.Molecular psychiatry · 2026Article
- Mitochondrial leak metabolism induces the Spemann-Mangold Organizer via Hif-1α in Xenopus.Developmental cell · 2023Article
- Morphologic and genic effects of waste pollution on the reproductive physiology ofFrontiers in physiology · 2023Article
- Gene Expression Detects the Factors Influencing the Reproductive Success and the Survival Rates ofInternational journal of molecular sciences · 2022Article
- PAHs and PCBs Affect Functionally Intercorrelated Genes in the Sea UrchinInternational journal of molecular sciences · 2021Article
- Sub-Chronic Effects of Slight PAH- and PCB-Contaminated Mesocosms inInternational journal of molecular sciences · 2021Article
- Two Benthic Diatoms,Marine drugs · 2021Article
- Article
- Diatom-Derived Polyunsaturated Aldehydes Activate Similar Cell Death Genes in Two Different Systems: Sea Urchin Embryos and Human Cells.International journal of molecular sciences · 2020Article
- Coupling feeding activity, growth rates and molecular data shows dietetic needs of Ciona robusta (Ascidiacea, Phlebobranchia) in automatic culture plants.Scientific reports · 2020Article
- Multiple Roles of Diatom-Derived Oxylipins within Marine Environments and Their Potential Biotechnological Applications.Marine drugs · 2020Review
- Types and Distribution of Bioactive Polyunsaturated Aldehydes in a Gradient from Mesotrophic to Oligotrophic Waters in the Alborán Sea (Western Mediterranean).Marine drugs · 2020Article
- Combined Effects of Diatom-Derived Oxylipins on the Sea UrchinInternational journal of molecular sciences · 2020Article
- Molecular and Morphological Toxicity of Diatom-Derived Hydroxyacid Mixtures to Sea UrchinMarine drugs · 2019Article
- Toxicity of diatom-derived polyunsaturated aldehyde mixtures on sea urchin Paracentrotus lividus development.Scientific reports · 2019Article
- Macroecological patterns of the phytoplankton production of polyunsaturated aldehydes.Scientific reports · 2018Article
- Toxigenic effects of two benthic diatoms upon grazing activity of the sea urchin: morphological, metabolomic and de novo transcriptomic analysis.Scientific reports · 2018Article
- New insights into negative effects of lithium on sea urchin Paracentrotus lividus embryos.Scientific reports · 2016Article
- First Morphological and Molecular Evidence of the Negative Impact of Diatom-Derived Hydroxyacids on the Sea Urchin Paracentrotus lividus.Toxicological sciences : an official journal of the Society of Toxicology · 2016Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Marine organisms possess a series of cellular strategies to counteract the negative effects of toxic compounds, including the massive reorganization of gene expression networks. Here we report the modulated dose-dependent response of activated genes by diatom polyunsaturated aldehydes (PUAs) in the sea urchin Paracentrotus lividus. PUAs are secondary metabolites deriving from the oxidation of fatty acids, inducing deleterious effects on the reproduction and development of planktonic and benthic organisms that feed on these unicellular algae and with anti-cancer activity. Our previous results showed that PUAs target several genes, implicated in different functional processes in this sea urchin. Using interactomic Ingenuity Pathway Analysis we now show that the genes targeted by PUAs are correlated with four HUB genes, NF-κB, p53, δ-2-catenin and HIF1A, which have not been previously reported for P. lividus. We propose a working model describing hypothetical pathways potentially involved in toxic aldehyde stress response in sea urchins. This represents the first report on gene networks affected by PUAs, opening new perspectives in understanding the cellular mechanisms underlying the response of benthic organisms to diatom exposure.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.