ArticleMedical research archives
Personalizing Medicine in Head and Neck Squamous Cell Carcinoma: The Rationale for Combination Therapies.
Article in Medical research archives. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Article
- Current Trends in Precision Medicine and Next-Generation Sequencing in Head and Neck Cancer.Current treatment options in oncology · 2022Review
- Rationale for the advancement of PI3K pathway inhibitors for personalized chordoma therapy.Journal of neuro-oncology · 2020Article
- The genomic landscape of UM-SCC oral cavity squamous cell carcinoma cell lines.Oral oncology · 2018Article
- Pathogenetic Analysis of Sinonasal Teratocarcinosarcomas Reveal Actionable β-catenin Overexpression and a β-catenin Mutation.Journal of neurological surgery. Part B, Skull base · 2017Article
- Correlation of Crtc1/3-Maml2 fusion status, grade and survival in mucoepidermoid carcinoma.Oral oncology · 2017Article
- Surveilling the Potential for Precision Medicine-driven PD-1/PD-L1-targeted Therapy in HNSCC.Journal of Cancer · 2017Review
- Genetic determinants in head and neck squamous cell carcinoma and their influence on global personalized medicine.Genes & cancer · 2016Article
- Article
- A review of drugs in development for the personalized treatment of head and neck squamous cell carcinoma.Expert review of precision medicine and drug development · 2016Article
- Differential compensation mechanisms define resistance to PI3K inhibitors inOtorhinolaryngology-head and neck surgery · 2016Article
- The potential for tumor suppressor gene therapy in head and neck cancer.Discovery medicine · 2016Review
- The Tip of the Iceberg: Clinical Implications of Genomic Sequencing Projects in Head and Neck Cancer.Cancers · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Personalized medicine, in which individual tumor genetics drive the selection of targeted therapies and treatment plans for each patient, has recently emerged as the next generation of cancer therapy. Unfortunately, personalized medicine trials have had limited success in tumors that have complex combinations of disruptive genomic events, which drive differential responses to targeted therapies. Here, we will use head and neck squamous cell carcinoma as a model for genetically complex disease and discuss novel approaches to enhance personalized medicine trials for these complicated cases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.