ReviewTherapeutic advances in psychopharmacology2016
Continuing clozapine treatment with lithium in schizophrenic patients with neutropenia or leukopenia: brief review of literature with case reports.
Review in Therapeutic advances in psychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 34 citations in OpenAlex.
- Effect of lithium on chemotherapy-induced neutropenia in Egyptian breast cancer patients; a prospective clinical study.Cancer chemotherapy and pharmacology · 2024Trial
- Changes in White Blood Cell and Neutrophil Counts in Patients With Schizophrenia Treated With Lithium Carbonate, Adenine, and Ninjin-Yoei-To: A Preliminary Study.Neuropsychopharmacology reports · 2026Article
- Can lithium be used in the setting of clozapine commencement in patients with COVID-19 associated neutropenia: A case report.Clinical case reports · 2024Article
- Valproate-related neutropenia and lithium-related leukocytosis in patients treated with clozapine: a retrospective cohort study.BMC psychiatry · 2023Article
- Clozapine Treatment Is Associated With Higher Prescription Rate of Antipsychotic Monotherapy and Lower Prescription Rate of Other Concomitant Psychotropics: A Real-World Nationwide Study.The international journal of neuropsychopharmacology · 2022Article
- Effect of antipsychotics on serum lithium levels and white blood cell counts.Neuropsychopharmacology reports · 2021Article
- Translational evidence for lithium-induced brain plasticity and neuroprotection in the treatment of neuropsychiatric disorders.Translational psychiatry · 2021Review
- Considerations of HLA, Renal Failure, Valproic Acid Use, and Current Treatment Guidelines in Clozapine-Induced Agranulocytosis.Case reports in psychiatry · 2021Article
- Effect of Intravenous Lipid Emulsion on Clozapine Acute Toxicity in Rats.Journal of pharmacopuncture · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveClozapine is a second-generation antipsychotic used for treatment-resistant schizophrenia. Despite its effectiveness, clozapine is largely underused due to serious side effects such as leukopenia or neutropenia. We aimed to review whether to continue, discontinue or rechallenge clozapine treatment after such haematological side effects.
methodsWe reviewed and summarized the literature on the use of clozapine, how to deal with its side effects, and suitable options in case of any haematological problems. Then, we described several cases successfully treated with clozapine and lithium after development of neutropenia or leukopenia.
resultsWe present three patients with treatment-resistant schizophrenia. While they had demonstrated poor response to multiple antipsychotic trials, clozapine was started. Clozapine induced neutropenia; or leukopenia developed in some cases that was successfully reversed after lithium onset. Increased serious side effects related with coprescription of lithium and clozapine were not observed.
conclusionLithium increases neutrophil and total white blood cell count as a side effect that may be useful in patients who develop neutropenia or leukopenia while being treated with clozapine.
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