ArticleClinical epigenetics2016
X chromosome-wide analysis identifies DNA methylation sites influenced by cigarette smoking.
Article in Clinical epigenetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Epigenome-wide association study of BMI in Black populations from InterGEN and GENOA.Obesity (Silver Spring, Md.) · 2023Pooled it
- Age-related DNA methylation on Y chromosome and their associations with total mortality among Chinese males.Aging cell · 2022Pooled it
- A Systematic Review of DNA Methylation and Preterm Birth in African American Women.Biological research for nursing · 2017Pooled it
- Identification of DNA methylation signatures of smoking in women and associations with cardiovascular disease mortality.Communications biology · 2026Article
- Article
- How do lifestyle and environmental factors influence the sperm epigenome? Effects on sperm fertilising ability, embryo development, and offspring health.Clinical epigenetics · 2025Review
- The X-factor in ART: does the use of assisted reproductive technologies influence DNA methylation on the X chromosome?Human genomics · 2023Article
- DNA-Methylation Signatures of Tobacco Smoking in a High Cardiovascular Risk Population: Modulation by the Mediterranean Diet.International journal of environmental research and public health · 2023Article
- Subacute and Chronic Spinal Cord Injury: A Scoping Review of Epigenetics and Secondary Health Conditions.Epigenetics insights · 2023Article
- Prenatal Maternal Smoke, DNA Methylation, and Multi-omics of Tissues and Child Health.Current environmental health reports · 2022Review
- High blood pressure in pregnancy, DNA methylation, and later blood pressure in African American women enrolled in the InterGEN Study.Birth (Berkeley, Calif.) · 2020Article
- Epigenetic Associations With Estimated Glomerular Filtration Rate Among Men With Human Immunodeficiency Virus Infection.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- Comparison of methylation patterns generated from genomic and cell-line derived DNA using the Illumina Infinium MethylationEPIC BeadChip array.BMC research notes · 2019Article
- Heritability of skewed X-inactivation in female twins is tissue-specific and associated with age.Nature communications · 2019Article
- DNA Methylation Markers of Type 2 Diabetes Mellitus Among Male Veterans With or Without Human Immunodeficiency Virus Infection.The Journal of infectious diseases · 2019Observational
- Novel DNA methylation sites associated with cigarette smoking among African Americans.Epigenetics · 2019Article
- Untargeted metabolomics reveals multiple metabolites influencing smoking-related DNA methylation.Epigenomics · 2018Article
- Joint Influence of SNPs and DNA Methylation on Lipids in African Americans From Hypertensive Sibships.Biological research for nursing · 2018Article
- Perceived Racial Discrimination and DNA Methylation Among African American Women in the InterGEN Study.Biological research for nursing · 2018Article
- Genes involved in development and differentiation are commonly methylated in cancers derived from multiple organs: a single-institutional methylome analysis using 1007 tissue specimens.Carcinogenesis · 2017Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundTobacco smoking is a major cause of chronic disease worldwide. Smoking may induce cellular and molecular changes including epigenetic modification, with both short-term and long-term modification patterns that may contribute to phenotypic expression of diseases. Recent epigenome-wide association studies (EWAS) have identified dozens of smoking-related DNA methylation (DNAm) sites. However, the X chromosomal DNAm sites have been largely overlooked due to a lack of an analytical framework for dealing with the sex-dimorphic distribution. To identify novel smoking-related DNAm sites on the X chromosome, we examined the modality of each X chromosomal DNAm site and conducted a sex-specific association study of cigarette smoking.
resultsWe used a discovery sample of 139 middle-age twins, and three replication samples of 78 twins, 464 and 333 unrelated individuals including 47, 17, 22, and 89 current smokers, respectively. After correction for multiple testing, the top smoking-related DNAm sites in BCOR and TSC22D3 were significantly hypermethylated and hypomethylated, respectively, among current smokers. These smoking-associated sites were replicated with meta-analysis p-values of 9.17 × 10(-12) and 1.61 × 10(-9). For both sites, the smoking effects on methylation levels were larger in males than that in females.
conclusionsOur findings highlight the importance of investigating X chromosome methylation patterns and their associations with environmental exposures and disease phenotypes and demonstrate a robust statistical methodology for such study. Existing EWAS of human diseases should incorporate the X chromosomal sites to complete a comprehensive epigenome-wide scan.
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