ArticleScience (New York, N.Y.)2016
Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children.
Article in Science (New York, N.Y.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05629624 (Multidimensional Evaluation of the Early Emergence of Executive Function and Emotional Regulation in Young Children in Bangladesh Using Nutritional and Psychosocial Intervention), which is not on this map. Cited by 444 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Multidimensional Evaluation of the Early Emergence of Executive Function and Emotional Regulation in Young Children in Bangladesh Using Nutritional and Psychosocial Intervention: A Pilot Study
Who cites it
444 citing papers in PubMed, 5 syntheses or guidelines pooled it, 724 citations in OpenAlex.
- Effects of Schistosoma haematobium infection and treatment on the systemic and mucosal immune phenotype, gene expression and microbiome: A systematic review.PLoS neglected tropical diseases · 2024Pooled it
- Systematic review of associations between gut microbiome composition and stunting in under-five children.NPJ biofilms and microbiomes · 2024Pooled it
- Early-life exposure to the Great Chinese Famine and gut microbiome disruption across adulthood for type 2 diabetes: three population-based cohort studies.BMC medicine · 2023Pooled it
- Probiotic Supplementation for Promotion of Growth in Children: A Systematic Review and Meta-Analysis.Nutrients · 2021Pooled it
- Understanding the gut microbiota and sarcopenia: a systematic review.Journal of cachexia, sarcopenia and muscle · 2021Pooled it
- Effects of Bifidobacterium animalis Subsp. Lactis CP-9 on Gut Microbiota and Immune Functions in Healthy Infants.Microbial biotechnology · 2026Trial
- Effect of a complementary feeding intervention based on iron- and zinc-biofortified pearl millet on the gut microbiota in 12-18-month-old children: a randomized trial.Nature communications · 2026Trial
- Trial
- A microbiome-directed therapeutic food for children recovering from severe acute malnutrition.Science translational medicine · 2024Trial
- A microbiota-directed complementary food intervention in 12-18-month-old Bangladeshi children improves linear growth.EBioMedicine · 2024Trial
- Trial
- Effect of Probiotic Supplementation on the Gut Microbiota Composition of Infants Delivered by Cesarean Section: An Exploratory, Randomized, Open-label, Parallel-controlled Trial.Current microbiology · 2023Trial
- Gut barrier and microbiota changes with glycine and branched-chain amino acid supplementation in chronic haemodialysis patients.Journal of cachexia, sarcopenia and muscle · 2021Trial
- Longitudinal assessments of child growth: A six-year follow-up of a cluster-randomized maternal education trial.Clinical nutrition (Edinburgh, Scotland) · 2021Trial
- Human fecal transplantation from stunted children promotes metabolic dysfunction in mice fed with a high-fat and high-fructose corn syrup diet.Gut microbes · 2026Article
- The putative role of the microbiota in the development of neuropsychiatric disorders following early childhood malnutrition.Gut microbes · 2026Review
- The JNK2-microbiome axis modulates gut barrier integrity through microbial acetate.Gut microbes · 2026Article
- Global analysis of infant gut microbiota revealed distinctive maturation dynamics across lifestyles.NPJ biofilms and microbiomes · 2026Article
- Local High-Protein, Plant-Based Ready-to-Use Therapeutic Food Enhances Recovery from Malnutrition in Rats.Current developments in nutrition · 2026Article
- Links between bone fractures and the gut microbiota.Nature reviews. Endocrinology · 2026Review
384 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
20 authors at 7 institutions in 5 countries.
Funding
Abstract
Undernourished children exhibit impaired development of their gut microbiota. Transplanting microbiota from 6- and 18-month-old healthy or undernourished Malawian donors into young germ-free mice that were fed a Malawian diet revealed that immature microbiota from undernourished infants and children transmit impaired growth phenotypes. The representation of several age-discriminatory taxa in recipient animals correlated with lean body mass gain; liver, muscle, and brain metabolism; and bone morphology. Mice were cohoused shortly after receiving microbiota from healthy or severely stunted and underweight infants; age- and growth-discriminatory taxa from the microbiota of the former were able to invade that of the latter, which prevented growth impairments in recipient animals. Adding two invasive species, Ruminococcus gnavus and Clostridium symbiosum, to the microbiota from undernourished donors also ameliorated growth and metabolic abnormalities in recipient animals. These results provide evidence that microbiota immaturity is causally related to undernutrition and reveal potential therapeutic targets and agents.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.