Evidence map›Paper›PMID 26912715›Full record

ReviewILAR journal2016

Review of Elephant Endotheliotropic Herpesviruses and Acute Hemorrhagic Disease.

Simon Y Long, Erin M Latimer, Gary S Hayward

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in ILAR journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
10.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 149 citations in OpenAlex.

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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Simon Y LongSimon Y. Long, MS, VMD, is a pathology postdoctoral fellow in the Department of Molecular and Comparative Pathobiology and a graduate student under Dr. Gary S. Hayward in the graduate program in Cellular and Molecular Medicine at Johns Hopkins School of Medicine in Baltimore, Maryland. Erin M. Latimer, MS, is a research specialist and manager of the National Elephant Herpesvirus Laboratory at the Smithsonian's National Zoological Park in Washington, DC. Gary S. Hayward, PhD, is a professor in the Viral Oncology Program, Pharmacology and Molecular Sciences, and Pathology Departments at Johns Hopkins School of Medicine in Baltimore, Maryland.
Erin M LatimerSimon Y. Long, MS, VMD, is a pathology postdoctoral fellow in the Department of Molecular and Comparative Pathobiology and a graduate student under Dr. Gary S. Hayward in the graduate program in Cellular and Molecular Medicine at Johns Hopkins School of Medicine in Baltimore, Maryland. Erin M. Latimer, MS, is a research specialist and manager of the National Elephant Herpesvirus Laboratory at the Smithsonian's National Zoological Park in Washington, DC. Gary S. Hayward, PhD, is a professor in the Viral Oncology Program, Pharmacology and Molecular Sciences, and Pathology Departments at Johns Hopkins School of Medicine in Baltimore, Maryland.
Gary S HaywardSimon Y. Long, MS, VMD, is a pathology postdoctoral fellow in the Department of Molecular and Comparative Pathobiology and a graduate student under Dr. Gary S. Hayward in the graduate program in Cellular and Molecular Medicine at Johns Hopkins School of Medicine in Baltimore, Maryland. Erin M. Latimer, MS, is a research specialist and manager of the National Elephant Herpesvirus Laboratory at the Smithsonian's National Zoological Park in Washington, DC. Gary S. Hayward, PhD, is a professor in the Viral Oncology Program, Pharmacology and Molecular Sciences, and Pathology Departments at Johns Hopkins School of Medicine in Baltimore, Maryland.
Smithsonian Institution · US

Funding

Training Program in Cellular and Molecular MedicineT32GM008752 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI RAO, RAJINI · 2000 to 2019
$11.7M
Training Veterinarians for Careers in Biomedical ResearchT32OD011089 · OD · JOHNS HOPKINS UNIVERSITY · PI JOSEPH L MANKOWSKI · 2012 to 2026
$6.7M
IMMEDIATE-EARLY REGULATORY GENES OF CYTOMEGALOVIRUSR01AI024576 · NIAID · JOHNS HOPKINS UNIVERSITY · PI HAYWARD, GARY S · 1987 to 2007
$2.0M
NIAID NIH HHS R01 AI024576NIAID NIH HHS R01 AI24576NIGMS NIH HHS T32 GM008752NIH HHS T32 OD011089
6 · The paper itself

Abstract

More than 100 young captive and wild Asian elephants are known to have died from a rapid-onset, acute hemorrhagic disease caused primarily by multiple distinct strains of two closely related chimeric variants of a novel herpesvirus species designated elephant endotheliotropic herpesvirus (EEHV1A and EEHV1B). These and two other species of Probosciviruses (EEHV4 and EEHV5) are evidently ancient and likely nearly ubiquitous asymptomatic infections of adult Asian elephants worldwide that are occasionally shed in trunk wash secretions. Although only a handful of similar cases have been observed in African elephants, they also have proved to harbor their own multiple and distinct species of Probosciviruses-EEHV2, EEHV3, EEHV6, and EEHV7-found in lung and skin nodules or saliva. For reasons that are not yet understood, approximately 20% of Asian elephant calves appear to be susceptible to the disease when primary infections are not controlled by normal innate cellular and humoral immune responses. Sensitive specific polymerase chain reaction (PCR) DNA blood tests have been developed, routine monitoring has been established, the complete large DNA genomes of each of the four Asian EEHV species have now been sequenced, and PCR gene subtyping has provided unambiguous evidence that this is a sporadic rather than epidemic disease that it is not being spread among zoos or other elephant housing facilities. Nevertheless, researchers have not yet been able to propagate EEHV in cell culture, determine whether or not human antiherpesvirus drugs are effective inhibitors, or develop serology assays that can distinguish between antibodies against the multiple different EEHV species.

Indexed as

AnimalsElephantsGenome, ViralHemorrhagic DisordersHerpesviridaeHerpesviridae InfectionsHost-Pathogen InteractionsViral Loadcalveselephant endotheliotropic herpesvirus (EEHV)elephant hemorrhagic diseaseElephas maximusLoxodonta Africanalung and skin nodulesProbosciviruses

Identifiers

PMID26912715
PMCPMC4765743
OpenAlexW2310833173

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.