ArticleBrain : a journal of neurology2016
Network-selective vulnerability of the human cerebellum to Alzheimer's disease and frontotemporal dementia.
Article in Brain : a journal of neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT07667478 (NON-INVASIVE BRAIN STIMULATION FOR MEMORY LOSS IN EARLY ALZHEIMER'S DISEASE), which is not on this map. Cited by 112 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Non-invasive brain stimulation for memory loss in early alzheimer's disease
Who cites it
112 citing papers in PubMed, 4 syntheses or guidelines pooled it, 215 citations in OpenAlex.
- Proposing a "Brain Health Checkup (BHC)" as a Global Potential "Standard of Care" to Overcome Reward Dysregulation in Primary Care Medicine: Coupling Genetic Risk Testing and Induction of "Dopamine Homeostasis".International journal of environmental research and public health · 2022Pooled it
- Differential vulnerability of the cerebellum in healthy ageing and Alzheimer's disease.NeuroImage. Clinical · 2021Pooled it
- The Cerebellum in Frontotemporal Dementia: a Meta-Analysis of Neuroimaging Studies.Neuropsychology review · 2019Pooled it
- Cerebellar volume and cerebellocerebral structural covariance in schizophrenia: a multisite mega-analysis of 983 patients and 1349 healthy controls.Molecular psychiatry · 2018Pooled it
- Does Functional Connectivity Provide a Marker for Cognitive Rehabilitation Effects in Alzheimer's Disease? An Interventional Study.Journal of Alzheimer's disease : JAD · 2017Trial
- Cerebellar Electrical Activity as a Marker for Predicting Brain Health and Disease: A Review.Brain sciences · 2026Review
- Cerebellar aging is spatially heterogeneous and supports cognitive resilience in later life.Nature neuroscience · 2026Article
- Right-lateralized cerebellar cortical thickening is associated with mild behavioral impairment in mild cognitive impairment.The journal of prevention of Alzheimer's disease · 2026Article
- Foreign Language Learning in Older Adults Modifies Resting-State Functional Connectivity Between the Subcortical Structures and the Cortex.Aging medicine (Milton (N.S.W)) · 2026Article
- Brain metabolic connectivity in ALS due to C9ORF72 hexanucleotide expansion: a [European journal of nuclear medicine and molecular imaging · 2026Article
- Functional connectivity patterns of the cerebellar components of intrinsic connectivity networks in clinically diagnosed probable Alzheimer's disease.BMC medical imaging · 2026Article
- Beyond the cerebral cortex: cerebellar language-related subregions contributions to fluency in post-stroke aphasia.NeuroImage. Clinical · 2026Article
- Association between neuroticism and brain-wide structural outcomes: Mediation by vascular and mental conditions.Psychological medicine · 2025Article
- Cerebellar Contributions to Spatial Learning and Memory: Effects of Discrete Immunotoxic Lesions.International journal of molecular sciences · 2025Article
- Assessing the link between cerebellar volume and cognitive function in Alzheimer's disease: a pilot study.Scientific reports · 2025Article
- Article
- Regional-specific structural and functional changes of posterior cerebellar vermis across different stages of Parkinson's disease with gait dysfunction.NPJ Parkinson's disease · 2025Article
- Differential Effects of Cerebellar tDCS on Sequential Mentalizing.Cerebellum (London, England) · 2025Article
- Alzheimer's disease cerebrospinal fluid biomarker levels and APOE genetic status are associated with hippocampal-cerebellar functional connectivity.Neurobiology of aging · 2025Article
- Sex-Associated Cerebellar and Hippocampal Volume Reduction in Alzheimer's Disease: Insights from the Clinical ADNI Cohort and STZ Animal Model.International journal of molecular sciences · 2025Article
52 more citing papers are in PubMed but not listed here.
Corrections and comments
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- Erratum issuedCorrigendum.2016
Authors and funding
6 authors at 5 institutions in 3 countries.
Funding
Abstract
SEE SCHMAHMANN DOI101093/BRAIN/AWW064 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: Neurodegenerative diseases are associated with distinct and distributed patterns of atrophy in the cerebral cortex. Emerging evidence suggests that these atrophy patterns resemble intrinsic connectivity networks in the healthy brain, supporting the network-based degeneration framework where neuropathology spreads across connectivity networks. An intriguing yet untested possibility is that the cerebellar circuits, which share extensive connections with the cerebral cortex, could be selectively targeted by major neurodegenerative diseases. Here we examined the structural atrophy in the cerebellum across common types of neurodegenerative diseases, and characterized the functional connectivity patterns of these cerebellar atrophy regions. Our results showed that Alzheimer's disease and frontotemporal dementia are associated with distinct and circumscribed atrophy in the cerebellum. These cerebellar atrophied regions share robust and selective intrinsic connectivity with the atrophied regions in the cerebral cortex. These findings for the first time demonstrated the selective vulnerability of the cerebellum to common neurodegenerative disease, extending the network-based degeneration framework to the cerebellum. Our work also has direct implications on the cerebellar contribution to the cognitive and affective processes that are compromised in neurodegeneration as well as the practice of using the cerebellum as reference region for ligand neuroimaging studies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.