ArticleJournal of neurophysiology2016
ON and OFF inhibition as mechanisms for forward masking in the inferior colliculus: a modeling study.
Article in Journal of neurophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Spatial separation between two sounds affects first-spike latencies of responses elicited by the sounds in the rat's auditory midbrain neurons.Scientific reports · 2025Article
- Forward masking in the inferior colliculus: Dynamics of discharge-rate recovery after narrowband noise maskers.The Journal of the Acoustical Society of America · 2025Article
- A Subcortical Model for Auditory Forward Masking with Efferent Control of Cochlear Gain.eNeuro · 2024Article
- Spatial-dependent suppressive aftereffect produced by a sound in the rat's inferior colliculus is partially dependent on local inhibition.Frontiers in neuroscience · 2023Article
- Foreground stimuli and task engagement enhance neuronal adaptation to background noise in the inferior colliculus of macaques.Journal of neurophysiology · 2020Article
- A generic deviance detection principle for cortical On/Off responses, omission response, and mismatch negativity.Biological cybernetics · 2019Article
- Responses of neurons in the rat's inferior colliculus to a sound are affected by another sound in a space-dependent manner.Scientific reports · 2019Article
- Nicotinic acetylcholine receptor subunit αJournal of neurophysiology · 2019Article
- Subcortical pathways: Towards a better understanding of auditory disorders.Hearing research · 2018Review
- Modeling Responses in the Superior Paraolivary Nucleus: Implications for Forward Masking in the Inferior Colliculus.Journal of the Association for Research in Otolaryngology : JARO · 2017Article
- Spatial and temporal disparity in signals and maskers affects signal detection in non-human primates.Hearing research · 2017Article
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1 author at 1 institution in 1 country.
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Abstract
Masking effects of a preceding stimulus on the detection or perception of a signal have been found in several sensory systems in mammals, including humans and rodents. In the auditory system, it has been hypothesized that a central "OFF-inhibitory" mechanism, which is generated by neurons that respond after a sound is terminated, may contribute to the observed psychophysics. The present study constructed a systems model for the inferior colliculus that includes major ascending monaural and binaural auditory pathways. The fundamental characteristics of several neuron types along the pathways were captured by Hodgkin-Huxley models with specific membrane and synaptic properties. OFF responses were reproduced with a model of the superior paraolivary nucleus containing a hyperpolarization-activated h current and a T-type calcium current. When the gap between the end of the masker and the onset of the signal was large, e.g., >5 ms, OFF inhibition generated strong suppressive effects on the signal response. For smaller gaps, an additional inhibitory source, which was modeled as ON inhibition from the contralateral dorsal nucleus of the lateral lemniscus, showed the potential of explaining the psychophysics. Meanwhile, the effect of a forward masker on the binaural sensitivity to a low-frequency signal was examined, which was consistent with previous psychophysical findings related to sound localization.
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