Evidence map›Paper›PMID 26912553›Full record

ArticleClinical journal of the American Society of Nephrology : CJASN2016

Genetic African Ancestry and Markers of Mineral Metabolism in CKD.

Orlando M Gutiérrez, Afshin Parsa, Tamara Isakova, Julia J Scialla, Jing Chen, John M Flack, Lisa C Nessel, Jayanta Gupta, Keith A Bellovich, Susan Steigerwalt and 6 more

Registry-linked trialOpen access · greenAbstract readComparative StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical journal of the American Society of Nephrology : CJASN, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04117204 (Identifying a Cardiorenal Protective Diet in a Lower-income African American Population With Chronic Kidney Disease at Risk for Cardiovascular Disease.), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04117204 nacompletednot on this mapstarted 2019, after this paper: background citation

Identifying a Cardiorenal Protective Diet in a Lower-income African American Population With Chronic Kidney Disease at Risk for Cardiovascular Disease.

TypeinterventionalSponsorBaylor Research InstituteRan2019 to 2020Enrolled101ConditionsChronic Kidney Diseases, Cardiovascular Diseases, HypertensionArmsFruits and Vegetables
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Genetic Variants Associated With Mineral Metabolism Traits in Chronic Kidney Disease.The Journal of clinical endocrinology and metabolism · 2022
    Article
  8. Article
  9. Article
  10. Race, Ancestry, and Vitamin D Metabolism: The Multi-Ethnic Study of Atherosclerosis.The Journal of clinical endocrinology and metabolism · 2020
    Article
  11. Predictors of Net Acid Excretion in the Chronic Renal Insufficiency Cohort (CRIC) Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2019
    Article
  12. Article
  13. Race, Serum Potassium, and Associations With ESRD and Mortality.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2017
    Observational
  14. Article
  15. Serum calcium and its complex association with incident type 2 diabetes.The American journal of clinical nutrition · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Orlando M GutiérrezDue to the number of contributing authors, the affiliations are provided in the Supplemental Material. ogutierr@uab.edu.
Afshin ParsaDue to the number of contributing authors, the affiliations are provided in the Supplemental Material.
Tamara IsakovaDue to the number of contributing authors, the affiliations are provided in the Supplemental Material.
Julia J SciallaDue to the number of contributing authors, the affiliations are provided in the Supplemental Material.
Jing ChenDue to the number of contributing authors, the affiliations are provided in the Supplemental Material.
John M FlackDue to the number of contributing authors, the affiliations are provided in the Supplemental Material.
Lisa C NesselDue to the number of contributing authors, the affiliations are provided in the Supplemental Material.
Jayanta GuptaDue to the number of contributing authors, the affiliations are provided in the Supplemental Material.
Keith A BellovichDue to the number of contributing authors, the affiliations are provided in the Supplemental Material.
Susan SteigerwaltDue to the number of contributing authors, the affiliations are provided in the Supplemental Material.
James H SondheimerDue to the number of contributing authors, the affiliations are provided in the Supplemental Material.
Jackson T WrightDue to the number of contributing authors, the affiliations are provided in the Supplemental Material.
Harold I FeldmanDue to the number of contributing authors, the affiliations are provided in the Supplemental Material.
John W KusekDue to the number of contributing authors, the affiliations are provided in the Supplemental Material.
James P LashDue to the number of contributing authors, the affiliations are provided in the Supplemental Material.
Myles WolfDue to the number of contributing authors, the affiliations are provided in the Supplemental Material.
University of Alabama at Birmingham · US

Funding

UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2M
Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
INSTITUTIONAL CLINICAL AND TRANSLATIONAL SCIENCE AWARDUL1RR024134 · NCRR · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2006 to 2011
$70.4M
MICHIGAN INSTITUTE FOR CLINICAL AND HEALTH RESEARCH (MICHR) (UL1): (BPCA)UL1RR024986 · NCRR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHANLEY, THOMAS P. · 2007 to 2011
$51.2M
Scientific and Data Coordinating Center(SDCC) for the P*U01DK060990 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI FELDMAN, HAROLD I · 2001 to 2017
$50.1M
Clinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0M
Michigan Institute for Clinical and Health Research (MCHR)UL1TR000433 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER · 2012 to 2016
$49.9M
Zonulin Antibodies in Intestinal Permeabilitiy in IDDMM01RR016500 · NCRR · UNIVERSITY OF MARYLAND BALTIMORE · PI OSWALD, LYNN M · 2002 to 2009
$20.2M
Study of the Care and Outcomes of REnal InsufficiencyU01DK060902 · NIDDK · KAISER FOUNDATION RESEARCH INSTITUTE · PI GO, ALAN S · 2001 to 2025
$19.5M
Limited Competition for the Continuation of the Chronic Renal Insufficiency CohorU01DK061021 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI RAHMAN, MAHBOOB · 2001 to 2025
$17.3M
Prospective Renal Insufficiency Cohort Evaluation:PRICEU01DK060984 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI COHEN, DEBBIE L · 2001 to 2025
$17.0M
Prospective Cohort Study of Chronic Renal InsufficiencyU01DK061028 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RAO, PANDURANGA S · 2001 to 2025
$16.9M
NCATS NIH HHS UL1 TR000433NCATS NIH HHS UL1 TR000439NCATS NIH HHS UL1TR000439NCRR NIH HHS M01 RR016500NCRR NIH HHS M01 RR-16500NCRR NIH HHS UL1 RR-024131NCRR NIH HHS UL1 RR024131NCRR NIH HHS UL1 RR-024134NCRR NIH HHS UL1 RR024134NCRR NIH HHS UL1 RR024986NCRR NIH HHS UL1RR024986NCRR NIH HHS UL1 RR-025005NCRR NIH HHS UL1 RR025005NCRR NIH HHS UL1 RR029879NCRR NIH HHS UL1RR029879NIDDK NIH HHS K23 DK095949NIDDK NIH HHS K24 DK093723NIDDK NIH HHS K24DK093723NIDDK NIH HHS R01 DK072231NIDDK NIH HHS R01 DK076116NIDDK NIH HHS R01DK076116NIDDK NIH HHS R01 DK081374NIDDK NIH HHS R01DK081374NIDDK NIH HHS R01 DK094796NIDDK NIH HHS R01DK094796NIDDK NIH HHS R01 DK139225NIDDK NIH HHS R03 DK095005NIDDK NIH HHS R03DK095005NIDDK NIH HHS R21 DK100754NIDDK NIH HHS R21DK100754NIDDK NIH HHS U01 DK060902NIDDK NIH HHS U01DK060902NIDDK NIH HHS U01 DK060963NIDDK NIH HHS U01DK060963NIDDK NIH HHS U01 DK060980NIDDK NIH HHS U01DK060980NIDDK NIH HHS U01 DK060984NIDDK NIH HHS U01DK060984NIDDK NIH HHS U01 DK060990NIDDK NIH HHS U01DK060990NIDDK NIH HHS U01 DK061021NIDDK NIH HHS U01DK061021NIDDK NIH HHS U01 DK061022NIDDK NIH HHS U01DK061022NIDDK NIH HHS U01 DK061028NIDDK NIH HHS U01DK061028NIDDK NIH HHS U01 DK099930NIDDK NIH HHS U01DK099930NIGMS NIH HHS P30 GM103337NIGMS NIH HHS P30GM103337NINDS NIH HHS R01 NS080850NINDS NIH HHS R01NS080850
6 · The paper itself

Abstract

BACKGROUND AND

objectivesDisorders of mineral metabolism are more common in African Americans with CKD than in European Americans with CKD. Previous studies have focused on the differences in mineral metabolism by self-reported race, making it difficult to delineate the importance of environmental compared with biologic factors. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: In a cross-sectional analysis of 3013 participants of the Chronic Renal Insufficiency Cohort study with complete data, we compared markers of mineral metabolism (phosphorus, calcium, alkaline phosphatase, parathyroid hormone, fibroblast growth factor 23, and urine calcium and phosphorus excretion) in European Americans versus African Americans and separately, across quartiles of genetic African ancestry in African Americans (n=1490).

resultsCompared with European Americans, African Americans had higher blood concentrations of phosphorus, alkaline phosphatase, fibroblast growth factor 23, and parathyroid hormone, lower 24-hour urinary excretion of calcium and phosphorus, and lower urinary fractional excretion of calcium and phosphorus at baseline (P<0.001 for all). Among African Americans, a higher percentage of African ancestry was associated with lower 24-hour urinary excretion of phosphorus (Ptrend<0.01) in unadjusted analyses. In linear regression models adjusted for socio-demographic characteristics, kidney function, serum phosphorus, and dietary phosphorus intake, higher percentage of African ancestry was significantly associated with lower 24-hour urinary phosphorus excretion (each 10% higher African ancestry was associated with 39.6 mg lower 24-hour urinary phosphorus, P<0.001) and fractional excretion of phosphorus (each 10% higher African ancestry was associated with an absolute 1.1% lower fractional excretion of phosphorus, P=0.01).

conclusionsA higher percentage of African ancestry was independently associated with lower 24-hour urinary phosphorus excretion and lower fractional excretion of phosphorus among African Americans with CKD. These findings suggest that genetic variability might contribute to racial differences in urinary phosphorus excretion in CKD.

Indexed as

AdultAgedBiomarkersBlack or African AmericanBlack PeopleCalciumCohort StudiesCross-Sectional StudiesFemaleHumansMaleMiddle AgedPhosphorusRenal Insufficiency, ChronicWhite PeopleYoung AdultBiomarkersCalciumPhosphorusAfrican Americanschronic kidney diseaseCohort StudiesFibroblast Growth FactorsHumansmineral metabolismparathyroid hormonePhosphorusRenal Insufficiency, Chronic

Identifiers

PMID26912553
PMCPMC4822668
OpenAlexW2288520313

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.