Evidence map›Paper›PMID 26912478›Full record

Trial reportThe journals of gerontology. Series A, Biological sciences and medical sciences2016

Preliminary Evidence That Excitatory Transcranial Direct Current Stimulation Extends Time to Task Failure of a Sustained, Submaximal Muscular Contraction in Older Adults.

Kentaro Oki, Niladri K Mahato, Masato Nakazawa, Shinichi Amano, Christopher R France, David W Russ, Brian C Clark

Open access · bronzeAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The journals of gerontology. Series A, Biological sciences and medical sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 3 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 42 citations in OpenAlex.

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  14. Neural Mechanisms of Age-Related Loss of Muscle Performance and Physical Function.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Kentaro OkiOhio Musculoskeletal & Neurological Institute, Department of Biomedical Sciences, and.
Niladri K MahatoOhio Musculoskeletal & Neurological Institute, Department of Biomedical Sciences, and.
Masato NakazawaOhio Musculoskeletal & Neurological Institute, Department of Biomedical Sciences, and.
Shinichi AmanoOhio Musculoskeletal & Neurological Institute, Clinical and Translational Research Unit, Ohio University, Athens.
Christopher R FranceOhio Musculoskeletal & Neurological Institute, Department of Psychology, Ohio University, Athens.
David W RussOhio Musculoskeletal & Neurological Institute, School of Rehabilitation & Communication Sciences, Ohio University, Athens.
Brian C ClarkOhio Musculoskeletal & Neurological Institute, Department of Biomedical Sciences, and clarkb2@ohio.edu.
Institute of Musculoskeletal Science & Education (United States) · USOhio University · US

Funding

Research Training in BiogerontologyT32AG000114 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SCOTT PLETCHER · 1985 to 2026
$12.4M
Neural mechanisms of dynapeniaR01AG044424 · NIA · OHIO UNIVERSITY ATHENS · PI CLARK, BRIAN C · 2014 to 2018
$1.4M
NIA NIH HHS R01 AG044424
6 · The paper itself

Abstract

backgroundDecreased cortical excitability has been proposed as a potential mechanism underlying task failure during sustained muscular contractions, and cortical excitability may decrease with old age. We tested the hypothesis that transcranial direct current stimulation, which has been reported to raise cortical excitability, would prolong the time to task failure during a sustained muscular contraction in older adults.

methodsThirteen older adults (68.3±2.0 years; eight women and five men) performed isometric, elbow flexions to failure while receiving sham or anodal transcranial direct current stimulation. Order of stimulation was randomized, and the subjects and investigators were blinded to condition. Time to task failure was measured alongside selected psychological indices of perceived exertion and affect.

resultsAnodal transcranial direct current stimulation prolonged mean time to task failure by approximately 15% (16.9±2.2 vs 14.7±1.8 minutes) and slowed the rate of increase in rating of perceived exertion (0.29±0.03 vs 0.31±0.03) relative to the sham condition.

conclusionsThese preliminary findings suggest that anodal transcranial direct current stimulation enhances time to task failure of a sustained, submaximal contraction in older adults by potentially increasing cortical excitability and/or influencing the perception of exertion. These results raise the question of whether interventions that acutely increase cortical excitability could enhance physical function and/or exercise-induced adaptations in older adults.

Indexed as

AgingMotor CortexMuscle ContractionMuscle FatigueMuscle, SkeletalTranscranial Direct Current StimulationAgedElbowEvoked Potentials, MotorFemaleHumansMalePsychomotor PerformanceSingle-Blind MethodTime FactorsFatigueMuscular contractionPerceived exertionStrengthTranscranial direct current stimulation

Identifiers

PMID26912478
PMCPMC4945887
OpenAlexW2281003595

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.