ArticleScientific reports2016
Infants and elderlies are susceptible to zinc deficiency.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 97 citations in OpenAlex.
- Olfactory Disturbances as Presenting Manifestation Among Egyptian Patients with COVID-19: Possible Role of Zinc.Biological trace element research · 2021Trial
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- The exploitation of nutrient metals by bacteria for survival and infection in the gut.PLoS pathogens · 2025Review
- Effect of aging on the development and progression of alcohol-associated liver disease.Alcohol, clinical & experimental research · 2025Article
- Rethinking Depression-Beyond Neurotransmitters: An Integrated Psychoneuroendocrineimmunology Framework for Depression's Pathophysiology and Tailored Treatment.International journal of molecular sciences · 2025Review
- Are Trace Elements Provided for Children on Long-Term Parenteral Nutrition Adequate to Meet Their Needs?Life (Basel, Switzerland) · 2024Article
- Zinc Toxicity: Understanding the Limits.Molecules (Basel, Switzerland) · 2024Review
- Dietary nutrient intake study among older adults: baseline Malaysian pure study.BMC geriatrics · 2024Article
- Demographic and clinical characteristics of patients with zinc deficiency: analysis of a nationwide Japanese medical claims database.Scientific reports · 2024Observational
- The global burden of high fasting plasma glucose associated with zinc deficiency: Results of a systematic review and meta-analysis.PLOS global public health · 2023Article
- Zinc homeostasis and redox alterations in obesity.Frontiers in endocrinology · 2023Review
- Serum zinc deficiency is a potential risk factor for the occurrence of levodopa-induced dyskinesia in drug-naïve Parkinson's disease.Frontiers in aging neuroscience · 2023Article
- Perspective: Role of Micronutrients and Omega-3 Long-Chain Polyunsaturated Fatty Acids for Immune Outcomes of Relevance to Infections in Older Adults-A Narrative Review and Call for Action.Advances in nutrition (Bethesda, Md.) · 2022Review
- Nutrition, Immunosenescence, and Infectious Disease: An Overview of the Scientific Evidence on Micronutrients and on Modulation of the Gut Microbiota.Advances in nutrition (Bethesda, Md.) · 2022Review
- Short-term zinc supplementation of zinc-deficient seniors counteracts CREMα - mediated IL-2 suppression.Immunity & ageing : I & A · 2022Article
- Antiviral and immunological activity of zinc and possible role in COVID-19.The British journal of nutrition · 2022Review
- Obesity and Leptin Resistance in the Regulation of the Type I Interferon Early Response and the Increased Risk for Severe COVID-19.Nutrients · 2022Review
- From the Bench to the Bedside: Branched Amino Acid and Micronutrient Strategies to Improve Mitochondrial Dysfunction Leading to Sarcopenia.Nutrients · 2022Review
- Association of zinc deficiency with infectious complications in pediatric hematopoietic stem cell transplantation patients.PloS one · 2022Article
- Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The importance of zinc for human health has been recognized since the early 1960s, but today there is little concern about zinc deficiency in developed countries. In this study, we measured the zinc concentration in hair from 28,424 Japanese subjects (18,812 females and 9,612 males) and found that 1,754 subjects (6.17%) had zinc concentrations lower than 2 standard deviations (86.3 ppm) below the control reference range, which qualifies as zinc deficiency. In particular, a considerable proportion of elderlies and children (20% or more) were found to have marginal to severe zinc deficiency. A zinc concentration of 9.7 ppm was the lowest observed in a 51-year-old woman; this concentration was approximately 1/13 of the mean reference level. The prevalence of zinc deficiency in adults increased with aging to a maximum of 19.7% by the 8(th) decade of life, and decreased to 3.4% above 90-year-old. The proportion of zinc deficiency in infants 0-4 years was 36.5% in males and 47.3% in females; these percentages were higher than the maximum prevalence in elderly subjects. These findings suggest that infants and elderlies are prone to zinc deficiency and that intervention of zinc deficiency is necessary for normal human development, health and longevity.
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