ArticleScientific reports2016
Sparse deconvolution of high-density super-resolution images.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 80 citations in OpenAlex.
- Computational Super-Resolution: An Odyssey in Harnessing Priors to Enhance Optical Microscopy Resolution.Analytical chemistry · 2025Review
- Localizing axial dense emitters based on single-helix point spread function and compressed sensing.Nanophotonics (Berlin, Germany) · 2025Article
- Review
- Super-Resolution Stimulated Raman Scattering Microscopy with Graphical User Interface-Supported A-PoD.Current protocols · 2024Article
- Resolution enhancement with deblurring by pixel reassignment (DPR).bioRxiv : the preprint server for biology · 2023Article
- Super-resolution SRS microscopy with A-PoD.Nature methods · 2023Article
- Fast and simple super-resolution with single images.Scientific reports · 2022Article
- State-of-the-Art Approaches for Image Deconvolution Problems, including Modern Deep Learning Architectures.Micromachines · 2021Review
- Parametric comparison between sparsity-based and deep learning-based image reconstruction of super-resolution fluorescence microscopy.Biomedical optics express · 2021Article
- Design of experiments for the optimization of SOFI super-resolution microscopy imaging.Biomedical optics express · 2021Article
- Smoothness correction for better SOFI imaging.Scientific reports · 2021Article
- A comprehensive review of deep learning-based single image super-resolution.PeerJ. Computer science · 2021Article
- Recent advances in point spread function engineering and related computational microscopy approaches: from one viewpoint.Biophysical reviews · 2020Review
- EXACT SPIKE TRAIN INFERENCE VIA ℓThe annals of applied statistics · 2018Article
- Computational multifocal microscopy.Biomedical optics express · 2018Article
- Quantum correlation enhanced super-resolution localization microscopy enabled by a fibre bundle camera.Nature communications · 2017Article
- Resolution enhancement with deblurring by pixel reassignment.Advanced photonicsArticle
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In wide-field super-resolution microscopy, investigating the nanoscale structure of cellular processes, and resolving fast dynamics and morphological changes in cells requires algorithms capable of working with a high-density of emissive fluorophores. Current deconvolution algorithms estimate fluorophore density by using representations of the signal that promote sparsity of the super-resolution images via an L1-norm penalty. This penalty imposes a restriction on the sum of absolute values of the estimates of emitter brightness. By implementing an L0-norm penalty--on the number of fluorophores rather than on their overall brightness--we present a penalized regression approach that can work at high-density and allows fast super-resolution imaging. We validated our approach on simulated images with densities up to 15 emitters per μm(-2) and investigated total internal reflection fluorescence (TIRF) data of mitochondria in a HEK293-T cell labeled with DAKAP-Dronpa. We demonstrated super-resolution imaging of the dynamics with a resolution down to 55 nm and a 0.5 s time sampling.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.