Understanding why clinicians should care about danger-associated molecular patterns.

Karim Asehnoune, Richard S Hotchkiss, Guillaume Monneret

Registry-linked trialAbstract readCommentEditorial

In one paragraph

Article in Intensive care medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03604731 (Persistent Multiorgan Failure in Intensive Care Units), which is not on this map. Cited by 5 papers.

0numbers the graph read from it

0cells of the map it votes in

5citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03604731 completednot on this mapstarted 2017, after this paper: background citation

Persistent Multiorgan Failure in Intensive Care Units: Risk Factors, Prognosis, Outcomes

Typeobservational_patient_registrySponsorResearch Institute for Complex Problems of Cardiovascular Diseases, RussiaRan2017 to 2020Enrolled300ConditionsSystemic Inflammatory Response Syndrome, Sepsis, Multiorgan FailureArmscytokine adsorbtion during extracorporeal circulation

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

Inflammatory Response and Anti-Inflammatory Treatment in Persistent Inflammation-Immunosuppression-Catabolism Syndrome (PICS).Journal of inflammation research · 2025
Review
Clinical treatment for persistent inflammation, immunosuppression and catabolism syndrome in patients with severe acute pancreatitis (Review).Experimental and therapeutic medicine · 2023
Review
Hypercatabolism and Anti-catabolic Therapies in the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome.Frontiers in nutrition · 2022
Review
Immunomonitoring of Monocyte and Neutrophil Function in Critically Ill Patients: From Sepsis and/or Trauma to COVID-19.Journal of clinical medicine · 2021
Review
PACMAN trial protocol, Perioperative Administration of Corticotherapy on Morbidity and mortality After Non-cardiac major surgery: a randomised, multicentre, double-blind, superiority study.BMJ open · 2019
Article

4 · The record

Corrections and comments

Comment on
Plasma levels of danger-associated molecular patterns are associated with immune suppression in trauma patients.2016

5 · Who and what money

Authors and funding

3 authors.

Karim AsehnouneDepartment of Anesthesiology and Critical Care Medicine, Hôtel Dieu, Centre hospitalier universitaire (CHU) de Nantes, 1 Place Alexis Ricordeau, 44000, Nantes, France. Karim.Asehnoune@chu-nantes.fr.

Richard S HotchkissDepartments of Anesthesiology, Medicine, and Surgery, Washington University School of Medicine, St Louis, MO, USA.

Guillaume MonneretImmunology Department, Hôpital Edouard Herriot , Hospices Civils de Lyon, 69003, Lyon, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID26912314

DOI10.1007/s00134-015-4198-y

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

NCT03604731ClinicalTrials.gov

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.