Evidence map›Paper›PMID 2691207›Full record

Trial reportControlled clinical trials1989

Measurement of health status. Ascertaining the minimal clinically important difference.

R Jaeschke, J Singer, G H Guyatt

8 registry-linked trialsAbstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in Controlled clinical trials, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 8 registered trials, which are not on this map. Cited by 1,751 papers, 24 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,751citing papers in PubMed, 24 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01459965 nacompletednot on this mapstarted 1993, after this paper: background citation

Endoscopic Palliation of Malignant Biliary Tract Obstruction: Emphasis on Improvement in Quality of Life

TypeinterventionalSponsorIndiana UniversityRan1993 to 2004Enrolled164ConditionsBile Duct Neoplasms MalignantArmsERCP with 10 French biliary plastic stent placement, ERCP with 11.5 French biliary plastic stent
NCT03692221 early_phase1withdrawnnot on this mapstarted 2019, after this paper: background citation

Percutaneous Image Guided Delivery of Autologous Bone Marrow Derived Mesenchymal Stem Cells for the Treatment of Symptomatic Degenerated Intervertebral Disc Disease

TypeinterventionalSponsorUniversity Hospitals Cleveland Medical CenterRan2019 to 2022Enrolled0ConditionsDisc DegenerationArmsMSC Treatment group 1 (low dose), MSC Treatment group 2 (high dose), Healthy Control (no treatment)
NCT05253157 completednot on this mapstarted 2020, after this paper: background citation

Changes in Pain Interference and Severity After an Episode of Virtual Reality-augmented Remote Rehabilitative Care: a Pragmatic Exploratory Descriptive Trial

TypeobservationalSponsorXRHealth USA Inc.Ran2020 to 2021Enrolled52ConditionsMusculoskeletal PainArmsVirtual Reality Augmented remote rehabilitation
NCT05412160 nacompletednot on this mapstarted 2023, after this paper: background citation

Improving Quality of Life and Daily Life Activities With Bioarginine in Patients With COPD: a Multicenter, Randomized, Controlled, Proof of Concept Study

TypeinterventionalSponsorUniversity of MilanRan2023 to 2024Enrolled153ConditionsCOPD, Dyspnea, ArgininemiaArmsArginine, Placebo
NCT05623085 nacompletednot on this mapstarted 2022, after this paper: background citation

Comparison of the Effects of Yoga and Aerobic Exercise Training in Primary Dysmenorrhea

TypeinterventionalSponsorHacettepe UniversityRan2022 to 2023Enrolled44ConditionsMenstrual Pain, DysmenorrheaArmsAerobic exercise, Yoga exercise
NCT06040866 nacompletednot on this mapstarted 2023, after this paper: background citation

Effects of Pain Neuroscience Education or Biomedical Pain Education With Exercise Training in Primary Dysmenorrhea: A Randomized Clinical Trial

TypeinterventionalSponsorHacettepe UniversityRan2023 to 2024Enrolled38ConditionsPrimary DysmenorrheaArmsExercise training, Pain neuroscience education, Biomedical pain education
NCT06562686 not yet recruitingnot on this mapstarted 2024, after this paper: background citation

Assessment of Methods Used in Evaluating Balance Rehabilitation in Parkinson's Patients: Determination of Responsiveness and Minimal Clinically Important Difference Values

TypeobservationalSponsorSultan Abdulhamid Han Training and Research Hospital, Istanbul, TurkeyRan2024 to 2025Enrolled83ConditionsParkinson Disease
NCT07700225 recruitingnot on this mapstarted 2026, after this paper: background citation

Establishing Biomarkers and Clinical Endpoints in Myotonic Dystrophy Type 1 (END-DM1) Extension

Typeobservational_patient_registrySponsorVirginia Commonwealth UniversityRan2026 to 2032Enrolled1,000ConditionsDM1, Myotonic Dystrophy, Myotonic Dystrophy 1, Myotonic Dystrophy Type 1
3 · Its place in the literature

Who cites it

1,751 citing papers in PubMed, 24 syntheses or guidelines pooled it.

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  13. Clinical relevance of patient-reported outcome measures in the surgical management of focal chondral defects of the knee: a systematic review.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2026
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  15. Eye Tracking as a Treatment Monitoring Tool for Autism: A Multilevel Meta-Analysis.Autism research : official journal of the International Society for Autism Research · 2025
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  17. A systematic review of minimum important changes for generic multi-attribute utility instruments and recommendations for their estimation.The European journal of health economics : HEPAC : health economics in prevention and care · 2025
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1,691 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

R JaeschkeDepartment of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.
J Singer
G H Guyatt

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years quality of life instruments have been featured as primary outcomes in many randomized trials. One of the challenges facing the investigator using such measures is determining the significance of any differences observed, and communicating that significance to clinicians who will be applying the trial results. We have developed an approach to elucidating the significance of changes in score in quality of life instruments by comparing them to global ratings of change. Using this approach we have established a plausible range within which the minimal clinically important difference (MCID) falls. In three studies in which instruments measuring dyspnea, fatigue, and emotional function in patients with chronic heart and lung disease were applied the MCID was represented by mean change in score of approximately 0.5 per item, when responses were presented on a seven point Likert scale. Furthermore, we have established ranges for changes in questionnaire scores that correspond to moderate and large changes in the domains of interest. This information will be useful in interpreting questionnaire scores, both in individuals and in groups of patients participating in controlled trials, and in the planning of new trials.

Indexed as

Health Status IndicatorsQuality of LifeActivities of Daily LivingAffective SymptomsAttitude to HealthClinical Trials as TopicData Interpretation, StatisticalDyspneaFatigueHeart DiseasesHumansLung DiseasesResearch DesignSurveys and Questionnaires

Identifiers

PMID2691207

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

and 2 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.