ArticleScientific reports2016
Quantitative imaging of gold nanoparticle distribution in a tumor-bearing mouse using benchtop x-ray fluorescence computed tomography.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed.
- Monte carlo study of detection limit for gold nanoparticles within small animal sized object during benchtop X-ray fluorescence computed tomography.Scientific reports · 2026Article
- Comparing the Achievable Sensitivity Limits of Synchrotron-based X-ray Fluorescence Imaging versus conventional X-ray absorption imaging and comparing absorbed dose levels including PET/SPECT.Zeitschrift fur medizinische Physik · 2026Review
- Review
- Mineralized Lipid Nanoparticles Containing Gadolinium Enable Integrated X-ray Fluorescence Computed Tomography Imaging and Radiotherapy.Nano letters · 2025Article
- Biodistribution of nanoplastics in mice: advancing analytical techniques using metal-doped plastics.Communications biology · 2025Article
- Deep learning based rapid X-ray fluorescence signal extraction and image reconstruction for preclinical benchtop X-ray fluorescence computed tomography applications.Scientific reports · 2025Article
- Fundamental study on improving the quality of X-ray fluorescence computed tomography images by applying deep image prior to projection images as a pre-denoising method.International journal of computer assisted radiology and surgery · 2025Article
- Monte Carlo Modeling of An Experimental Benchtop L-shell X-ray Fluorescence Imaging/CT System Adopting Two Silicone Drift Detectors.Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment · 2025Article
- Contrast-to-noise ratio comparison between X-ray fluorescence emission tomography and computed tomography.Journal of medical imaging (Bellingham, Wash.) · 2024Article
- Iodinated PSMA Ligands as XFI Tracers for Targeted Cell Imaging and Characterization of Nanoparticles.International journal of molecular sciences · 2024Article
- Enabling Low-Dose In Vivo Benchtop X-ray Fluorescence Computed Tomography through Deep-Learning-Based Denoising.Journal of imaging · 2024Article
- A High-Sensitivity Benchtop X-Ray Fluorescence Emission Tomography (XFET) System With a Full-Ring of X-Ray Imaging-Spectrometers and a Compound-Eye Collimation Aperture.IEEE transactions on medical imaging · 2024Article
- Gold nanoparticle-mediated photothermal therapy guidance with multi-wavelength photomagnetic imaging.Photodiagnosis and photodynamic therapy · 2024Article
- Laboratory Liquid-Jet X-ray Microscopy and X-ray Fluorescence Imaging for Biomedical Applications.International journal of molecular sciences · 2024Article
- Effect of detector placement on joint estimation in X-ray fluorescence emission tomography.IEEE transactions on radiation and plasma medical sciences · 2024Article
- Enabling X-ray fluorescence imaging for in vivo immune cell tracking.Scientific reports · 2023Article
- Review of Development and Recent Advances in Biomedical X-ray Fluorescence Imaging.International journal of molecular sciences · 2023Review
- Joint Estimation of Metal Density and Attenuation Maps with Pencil Beam XFET.IEEE transactions on radiation and plasma medical sciences · 2023Article
- Pancreatic tumor microenvironmental acidosis and hypoxia transform gold nanorods into cell-penetrant particles for potent radiosensitization.Science advances · 2022Article
- Chemical Overview of Gel Dosimetry Systems: A Comprehensive Review.Gels (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
X-ray fluorescence computed tomography (XFCT) is a technique that can identify, quantify, and locate elements within objects by detecting x-ray fluorescence (characteristic x-rays) stimulated by an excitation source, typically derived from a synchrotron. However, the use of a synchrotron limits practicality and accessibility of XFCT for routine biomedical imaging applications. Therefore, we have developed the ability to perform XFCT on a benchtop setting with ordinary polychromatic x-ray sources. Here, we report our postmortem study that demonstrates the use of benchtop XFCT to accurately image the distribution of gold nanoparticles (GNPs) injected into a tumor-bearing mouse. The distribution of GNPs as determined by benchtop XFCT was validated using inductively coupled plasma mass spectrometry. This investigation shows drastically enhanced sensitivity and specificity of GNP detection and quantification with benchtop XFCT, up to two orders of magnitude better than conventional x-ray CT. The results also reaffirm the unique capabilities of benchtop XFCT for simultaneous determination of the spatial distribution and concentration of nonradioactive metallic probes, such as GNPs, within the context of small animal imaging. Overall, this investigation identifies a clear path toward in vivo molecular imaging using benchtop XFCT techniques in conjunction with GNPs and other metallic probes.
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