ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2016
Human Hippocampal Structure: A Novel Biomarker Predicting Mnemonic Vulnerability to, and Recovery from, Sleep Deprivation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 63 citations in OpenAlex.
- Article
- Sleep facilitates pattern separation through SK channel-mediated sparse coding.Current biology : CB · 2026Article
- Memory consolidation during sleep: a facilitator of new learning?Neuropsychologia · 2026Review
- Long non-coding RNA Cerox1 targets components of the mitochondrial electron transport chain to regulate the memory impairment caused by sleep deprivation.Research square · 2025Article
- Independent associations of sleep and physical activity with cognition are mediated by hippocampal microstructure in middle-aged and older adults.Neurobiology of aging · 2025Article
- The need for details for object discrimination and mnemonic discrimination.Frontiers in cognition · 2025Article
- Sleep restriction impairs item memory discrimination but not general recognition in young adolescents.Sleep advances : a journal of the Sleep Research Society · 2025Article
- Memory Reactivation during Sleep Does Not Act Holistically on Object Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Memory reactivation during sleep does not act holistically on object memory.bioRxiv : the preprint server for biology · 2024Article
- Is Short Sleep Bad for the Brain? Brain Structure and Cognitive Function in Short Sleepers.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Recovery sleep attenuates impairments in working memory following total sleep deprivation.Frontiers in neuroscience · 2023Article
- Optimizing the mnemonic similarity task for efficient, widespread use.Frontiers in behavioral neuroscience · 2023Article
- Review
- Investigating the effects of sleep and sleep loss on the different stages of episodic emotional memory: A narrative review and guide to the future.Frontiers in behavioral neuroscience · 2022Review
- Cardiorespiratory Fitness May Protect Memory for Poorer Sleepers.Frontiers in psychology · 2022Article
- Right stellate ganglion block improves learning and memory dysfunction and hippocampal injury in rats with sleep deprivation.BMC anesthesiology · 2021Article
- Sleep deprivation results in diverse patterns of synaptic scaling across the Drosophila mushroom bodies.Current biology : CB · 2021Article
- Differential effect of sleep deprivation on place cell representations, sleep architecture, and memory in young and old mice.Cell reports · 2021Article
- Harnessing the Neurobiology of Resilience to Protect the Mental Well-Being of Healthcare Workers During the COVID-19 Pandemic.Frontiers in psychology · 2021Review
- Roles for Sleep in Neural and Behavioral Plasticity: Reviewing Variation in the Consequences of Sleep Loss.Frontiers in behavioral neuroscience · 2021Review
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Sleep deprivation impairs the formation of new memories. However, marked interindividual variability exists in the degree to which sleep loss compromises learning, the mechanistic reasons for which are unclear. Furthermore, which physiological sleep processes restore learning ability following sleep deprivation are similarly unknown. Here, we demonstrate that the structural morphology of human hippocampal subfields represents one factor determining vulnerability (and conversely, resilience) to the impact of sleep deprivation on memory formation. Moreover, this same measure of brain morphology was further associated with the quality of nonrapid eye movement slow wave oscillations during recovery sleep, and by way of such activity, determined the success of memory restoration. Such findings provide a novel human biomarker of cognitive susceptibility to, and recovery from, sleep deprivation. Moreover, this metric may be of special predictive utility for professions in which memory function is paramount yet insufficient sleep is pervasive (e.g., aviation, military, and medicine).
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.